Abstract
Purpose:
To describe the 10-year incidence of localized retina nerve fiber layer (RNFL) defects and its risk factors in adult Chinese.
Methods:
The Beijing Eye Study is a population-based, cohort study, which included 4439 subjects (40 years and older) of Beijing China in 2001 as baseline survey, and was re-conducted in 2011 with 2695 subjects (aged 50 years and older) participating (66.4% of the survivors). Participants underwent retinal photography and localized RNFL defects were evaluated by one trained ophthalmologists. Localized RNFL defects were defined as wedge-shaped defects running towards the optic disc. The eyes with localized RNFL defects 10 years ago and their ranges of defect enlarged during the 10 years were included. In addition, its associated risk factors were obtained from clinical examination and questionnaires.
Results:
The incident localized retina nerve fiber layer defects were detected in 114/2422 persons (mean±SE, 4.7%±0.2%) and 139/4867 eyes (2.9%±0.2%). In multivariate analysis, the incidence of localized RNFL defect were significantly associated with the rural region residency (P=0.007; OR=1.98; 95% CI:1.20, 3.23), lower cognitive function score (P=0.009; OR=1.06; 95% CI:1.02, 1.12), had more often hypertension (P=0.015; OR=1.69; 95% CI:1.11, 2.56 ), diabetes (P=0.001; OR=2.34; 95% CI:1.42, 3.84), diabetic retinopathy (P=0.024; OR=3.10; 95% CI:1.16, 8.28), cerebral infarction or hemorrhages (P=0.000; OR=2.95; 95% CI:1.42, 6.14) and glaucoma (P=0.000; OR=46.62; 95% CI:24.49, 88.74), not significantly associated with intraocular pressure (p=0.324), systolic blood pressure (P=0.892), diastolic blood pressure (P=0.262) and body mass index (BMI) (P=0.142).
Conclusions:
The 10-year incidence of localized RNFL defects in 40 years old or more Chinese is 4.7%±0.2%. It is associated with the rural region residency, lower cognitive function score, hypertension history, diabetes history, diabetic retinopathy, cerebral infarction or hemorrhages and glaucoma.
Keywords: 463 clinical (human) or epidemiologic studies: prevalence/incidence