April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Pupil Analysis in African-Americans with Long Anterior Lens Zonules
Author Affiliations & Notes
  • Daniel K Roberts
    Clinical Education, Illinois College of Optometry, Chicago, IL
    Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL
  • Yongyi Yang
    Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, IL
    Predictek, Inc., Chicago, IL
  • Ana Lukic
    Predictek, Inc., Chicago, IL
  • Jacob T Wilensky
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL
  • Miles Wernick
    Department of Electrical and Computer Engineering, Illinois Institute of Technology, Chicago, IL
    Predictek, Inc., Chicago, IL
  • Footnotes
    Commercial Relationships Daniel Roberts, Predictek, Inc. (P); Yongyi Yang, Predictek, Inc. (P); Ana Lukic, Predictek, Inc. (P); Jacob Wilensky, None; Miles Wernick, Predictek, Inc. (P)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4303. doi:
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      Daniel K Roberts, Yongyi Yang, Ana Lukic, Jacob T Wilensky, Miles Wernick; Pupil Analysis in African-Americans with Long Anterior Lens Zonules. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4303.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Long anterior zonules (LAZ), which are characterized by zonular fibers that extend more central than usual on the anterior lens capsule, could be be a risk factor for open- and narrow-angle glaucoma. Studies so far have shown LAZ to be associated with female gender, older age, hyperopia, shorter axial length, remnants of the tunica vasculosa lentis, and pigment dispersion. We investigated the hypothesis that LAZ are also more likely to have mild dyscoria, possibly due to chronic irido-zonular rubbing, concentrated mainly in the pupillary region.

Methods: We reviewed a near infrared iris transillumination (NIRit) database that contained a variety of subjects and selected LAZ and normal eyes for comparison. All eyes had been previously imaged using a modified digital camera (COOLPIX 950, Nikon Corp, Tokyo, Japan) to photograph the iris while it was illuminated with visible and infrared light via a standard ophthalmic transilluminator directed against the inferior eyelid. Pupil contour lines were created using an automated computer algorithm, and measures of pupil shape were calculated, including pupil roundness (PR), pupil ovalness (PO), pupil circularity index (PCI), pupil size (PS), and pupil eccentricity (PE). Regression analyses were used to assess pupil feature differences between LAZ and normal eyes. Because African-American females comprised the vast majority of LAZ eyes in the database, only this subject group was included in the analysis.

Results: There were 41 LAZ females with a mean age = 68.3 years +/- 11.8 years (44-92 years) and 72 normals with a mean age = 45.0 years +/- 13.7 years (18-75 years). Controlling for age and pupil size (PS), LAZ right eyes showed PO measures (P=0.001), PR measures (P=0.002), and PCI measures (P=0.001) that were significantly different from normal right eyes. PE measures were marginally significantly different (P=0.03).

Conclusions: In addition to signs previously described, the clinical features of LAZ eyes may also include pupil dyscoria. This may be helpful toward the emerging understanding of the LAZ clinical trait.

Keywords: 667 pupil • 571 iris • 461 clinical (human) or epidemiologic studies: natural history  

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