April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Subfoveal Choroidal Thickness and Cerebrospinal Fluid Pressure. The Beijing Eye Study 2011
Jost B Jonas; Ningli Wang; Ya Xing Wang; Qisheng You; Diya Yang; Xiao B Xie; Wen B Wei; Liang Xu
Author Affiliations & Notes
  • Jost B Jonas
    Ophthalmology, Medical Faculty Mannheim-Heidelberg, Mannheim, Germany
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
  • Ningli Wang
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
  • Ya Xing Wang
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
  • Qisheng You
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
  • Diya Yang
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
  • Xiao B Xie
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
  • Wen B Wei
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China
  • Liang Xu
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China
  • Footnotes
    Commercial Relationships Jost Jonas, None; Ningli Wang, None; Ya Xing Wang, None; Qisheng You, None; Diya Yang, None; Xiao Xie, None; Wen Wei, None; Liang Xu, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4336. doi:
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      Jost B Jonas, Ningli Wang, Ya Xing Wang, Qisheng You, Diya Yang, Xiao B Xie, Wen B Wei, Liang Xu; Subfoveal Choroidal Thickness and Cerebrospinal Fluid Pressure. The Beijing Eye Study 2011. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4336.

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Abstract

Purpose: The venous choroidal blood drains through the superior orbital vein into the intracranial cavernous sinus. The cerebrospinal fluid pressure (CSFP) may thus influence the choroidal venous blood pressure. Since volume and thickness of the choroid depend on its pressure, we tested the hypothesis whether the subfoveal choroidal thickness (SFCT) is associated with CSFP.

Methods: The population-based Beijing Eye Study 2011 included 3468 individuals. A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (SD-OCT) with enhanced depth imaging for measurement of SFCT. CSFP was calculated as CSFP[mmHg]=0.44xBody Mass Index[kg/m2]+0.16xDiastolic Blood Pressure[mmHg]-0.18 x Age[Years]-1.91.

Results: Mean calculated CSFP was 8.8±3.7 mm Hg and mean SFCT was 254±107μm. In multivariate analysis, SFCT was significantly associated with higher CSFP (P=0.009; standardized coefficient beta:0.08; regression coefficient B:2.27) after adjusting for lower age (P<0.001;beta:-0.36;B:-3.99), shorter axial length (P<0.001;beta:-0.37;B:-35.7), lower body mass index (P=0.02;beta:-0.05;B:-1.51) and higher corneal curvature radius (P<0.001;beta:0.10;B:41.1). In univariate analysis, SFCT increased by 9.2 μm (95% confidence interval: 8.3,10.1) for each mmHg increase in CSFP. In a reverse manner, CSFP was significantly associated with thicker SFCT (P<0.001;B:0.007;beta:0.21), after adjusting for region of habitation (P<0.001;B:-0.31;beta:-2.32), higher levels of glucose (P=0.02;B:0.10;beta:0.04) and triglycerides (P<0.001;B:0.13;beta:0.09), higher intraocular pressure (P<0.001;B:0.17;beta:0.12), and thinner lens (P<0.001;B:-2.39;beta:-0.22).

Conclusions: Thicker subfoveal choroid was associated with higher CSFP after adjustment for age, axial length, body mass index and corneal curvature radius. This association may explain thicker SFCT measurements in the morning than evening. It shows the importance of the CSFP for the physiology of the eye.

Keywords: 452 choroid • 613 neuro-ophthalmology: optic nerve • 585 macula/fovea  
© 2014, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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