Abstract
Purpose:
To study retinal function in asymptomatic type 1 and 2 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and no clinical signs of diabetic macular edema (DME).
Methods:
Thirty-six consecutive type 1 and 2 diabetic patients with NPDR and no DME, and 28 healthy controls, underwent a complete ophthalmologic examination, including spectral-domain optical coherence tomography (SD-OCT) and microperimetry.
Results:
Thirty-six consecutive type 1 and 2 diabetic patients with NPDR and no DME, and 28 healthy controls, underwent a complete ophthalmologic examination, including spectral-domain optical coherence tomography (SD-OCT) and microperimetry. Results: Seventy-one eyes (17 with type 1 and 19 with type 2 diabetes) were included in this study. Mean best-corrected visual acuity was 0.00±0.01 LogMAR and 0.00±0.02 LogMAR for type 1 and type 2 diabetic patients, respectively (p=0.075). Mean central foveal thickness (CFT) was 234.5 ±13.7 µm and 256.3 ±12.7 µm for type 1 and type 2 diabetes, respectively (p=0.04), the CFT was statistically different compared with the control groups (p=0.04 and p=0.01, respectively). Mean retinal sensitivity was 18.9±0.5 dB and 17.7±0.4 dB for type 1 and type 2 diabetes, respectively; it was statistically different compared with the control groups (p<0.0001 and p<0.0001, respectively).
Conclusions:
We demonstrated a significantly reduced sensitivity in both types asymptomatic NPDR patients without DME compared with healthy controls, this reduction was greater in type 2 diabetic patients. CFT was increased in both diabetic groups compared with control groups, despite the absence of DME.
Keywords: 499 diabetic retinopathy •
550 imaging/image analysis: clinical •
507 electrophysiology: clinical