April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
DIABETIC RETINOPATHY - NEURODEGENERATIVE DISEASE ?
Author Affiliations & Notes
  • Joana Ferreira
    Ophthalmology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Arnaldo Dias Santos
    Ophthalmology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • luisa vieira
    Ophthalmology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Duarte Amado
    Ophthalmology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • João Paulo Cunha
    Ophthalmology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
  • Luis Abegão Pinto
    Ophthalmology, Centro Hospitalar de Lisboa Central, Lisboa, Portugal
    Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
  • Footnotes
    Commercial Relationships Joana Ferreira, None; Arnaldo Santos, None; luisa vieira, None; Duarte Amado, None; João Paulo Cunha, None; Luis Abegão Pinto, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4419. doi:
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      Joana Ferreira, Arnaldo Dias Santos, luisa vieira, Duarte Amado, João Paulo Cunha, Luis Abegão Pinto; DIABETIC RETINOPATHY - NEURODEGENERATIVE DISEASE ?. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4419.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The purpose of this study was to evaluate the changes in retinal thickness, particularly in layer ganglion cells, in diabetic patients without diabetic retinopathy, and to investigate the possible relationship between this thickness and duration of diabetes mellitus.

Methods: The study included 20 patients (40 eyes) with diabetes mellitus without diabetic retinopathy and 20 subjects (40 eyes) controls. We measured the retinal thickness(RT) in the fovea, parafovea and perifovea (1, 3, 6mm ETDRS), as well as GCL + IPL thickness in 2 and 3 mm ETDRS, with spectral domain optical coherence tomography (SD-OCT).

Results: A significant decrease of RT was found in diabetics eyes versus controls (p<0,05), in superior, inferior and nasal inner quadrant. A significant decrease of GCL + IPL was, also, found in diabetics eyes versus controls in nasal inner and outer quadrant (p < 0,01). Significant correlation was found between duration of diabetes and nasal CGL + IPL thickness.

Conclusions: The results suggest the loss of intraretinal neural tissue in diabetic patients without clinically detectable retinopathy and support the concept that early diabetic retinopathy includes a neurodegenerative component. SD-OCT may be useful tool to diagnose early neurodegenerative changes in diabetic retinopathy.

Keywords: 499 diabetic retinopathy • 531 ganglion cells • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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