April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Author Affiliations & Notes
  • Benedicte Dupas
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Sylvie Feldman-Billard
    Diabetology, CHNO XV VV, Paris, France
  • Emmanuel L B H Bui Quoc
    Ophthalmology, Hôpital Robert Debré, Paris, France
  • Ali Erginay
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Pierre-Jean Guillausseau
    Internal Medicine, Lariboisière Hospital, Paris, France
  • Pascale G Massin
    Ophthalmology, Lariboisière Hospital, Paris, France
  • Footnotes
    Commercial Relationships Benedicte Dupas, None; Sylvie Feldman-Billard, None; Emmanuel Bui Quoc, None; Ali Erginay, None; Pierre-Jean Guillausseau, None; Pascale Massin, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4436. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Benedicte Dupas, Sylvie Feldman-Billard, Emmanuel L B H Bui Quoc, Ali Erginay, Pierre-Jean Guillausseau, Pascale G Massin; INFLUENCE OF PULSE PRESSURE AND SPONTANEOUS VARIATIONS OF MACULAR THICKNESS IN PATIENTS WITH DIABETIC MACULAR EDEMA. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4436.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: To study spontaneous variations of central macular thickness (CMT) and its relation to blood pressure (BP) in patients with diabetic macular edema (DME)

Methods: 23 diabetic patients presenting with DME with a CMT ≥ 260 µm on Optical Coherence Tomography (OCT-3, Carl Zeiss Meditec, CA) were followed every 2 weeks for three months. At baseline, ambulatory 24H-BP monitoring (ABPM) was performed, as well as five CMT measurements (9am, 12am, 3pm, 6pm and 9am the day after). During follow up, BP and CMT were simultaneously measured at 9am.

Results: Significant spontaneous variations in CMT (at least one change in CMT greater than 11% compared to the median CMT value) were observed over 3 months in 48% of patients. Mean CMT decreased over the day and increased during the night, but not significantly (P = 0.1). During the 6 visits, the CMT at 9am positively correlated with the Pulse Pressure (PP) measured at the same time (r = 0.29, P =0.0008). In addition, the mean 24H -CMT was positively correlated with the mean 24H- PP (r = 0.48, P = 0.02).

Conclusions: Significant spontaneous changes in CMT of patients with DME were observed in nearly half of cases over 3 months. Retinal thickness was correlated to PP levels (patients with higher CMT had higher PP levels). This high variability of macular edema, and the influence of BP on retinal thickness, should be taken into consideration by practitioners when evaluating the benefit of a therapy in DME.

Keywords: 688 retina • 499 diabetic retinopathy • 505 edema  

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.