April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Optic Nerve Morphology in Normal Children
Author Affiliations & Notes
  • Devang L Bhoiwala
    Ophthalmology, Albany Medical College, Albany, NY
  • Preethi Raghu
    Ophthalmology, Albany Medical College, Albany, NY
  • Mala Krishnamoorthy
    Ophthalmology, Albany Medical College, Albany, NY
  • Amit Todani
    Ophthalmology, Albany Medical College, Albany, NY
  • Sai B Gandham
    Ophthalmology, Albany Medical College, Albany, NY
  • Steven Simmons
    Ophthalmology, Albany Medical College, Albany, NY
  • John Simon
    Ophthalmology, Albany Medical College, Albany, NY
  • Footnotes
    Commercial Relationships Devang Bhoiwala, None; Preethi Raghu, None; Mala Krishnamoorthy, None; Amit Todani, None; Sai Gandham, None; Steven Simmons, None; John Simon, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4477. doi:
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      Devang L Bhoiwala, Preethi Raghu, Mala Krishnamoorthy, Amit Todani, Sai B Gandham, Steven Simmons, John Simon; Optic Nerve Morphology in Normal Children. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4477.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Although optic nerve morphology is routinely assessed in adults, no normative data base has been established for young children. We undertook to characterize the morphology of optic nerves of healthy 5 year-olds.

Methods: A series of 71 children undergoing pre-school physicals were recruited from local pediatric practices for an ongoing cross-sectional study. None had a history of glaucoma or other optic nerve disorders. All underwent standard ophthalmologic examination and imaging of their optic nerves using optical coherence tomography (OCT). Results were compared to the normative adult database.

Results: OCT demonstrated mean nerve fiber layer (NFL) thickness of 1.632 (p=0.332), superior NFL thickness of 0.181 (p=0.920), inferior NFL thickness of 3.082 (p= 0.091), and mean thickness of ganglion cell complex of 0.130 (p =0.068). OCT values for the optic nerve head include disc area of -0.186 (p=0.007), Area of Cup to disc (C.D.) ratio of -0.103 (p= 4.96E-05), Horizontal C.D. ratio of -0.181 (p= 3.08E-06), vertical C.D. ratio of -0.139 (p= 5.19E-05), and cup area of -0.272 (p= 2.06E-05).

Conclusions: This study presents the first quantitative assessment of the optic nerve head, nerve fiber layer, and ganglion cell complex of young children. Our results demonstrate that the optic nerves of 5 year old children are statistically smaller and have a smaller cup when compared with normal adult values. The nerve fiber layer and GCC data in the children was similar to the adult normals.

Keywords: 627 optic disc • 757 visual development: infancy and childhood • 629 optic nerve  

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