April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Choroidal Abnormalities in Neurofimomatosis type 1 detected by Near-Infrared Reflectance Imaging in paediatric population
Author Affiliations & Notes
  • Aldo Vagge
    Ophthalmology, DINOGMI, University of Genoa, Genoa, Italy
  • Paola Camicione
    Ophthalmology, Gaslini Children's Hospital, Genoa, Italy
  • Cristina Capris
    Ophthalmology, DINOGMI, University of Genoa, Genoa, Italy
  • Carlo Sburlati
    Ophthalmology, Gaslini Children's Hospital, Genoa, Italy
  • Simona Panarello
    Ophthalmology, Gaslini Children's Hospital, Genoa, Italy
  • Carlo Enrico Traverso
    Ophthalmology, DINOGMI, University of Genoa, Genoa, Italy
  • Paolo Capris
    Ophthalmology, Gaslini Children's Hospital, Genoa, Italy
  • Footnotes
    Commercial Relationships Aldo Vagge, None; Paola Camicione, None; Cristina Capris, None; Carlo Sburlati, None; Simona Panarello, None; Carlo Enrico Traverso, None; Paolo Capris, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4490. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Aldo Vagge, Paola Camicione, Cristina Capris, Carlo Sburlati, Simona Panarello, Carlo Enrico Traverso, Paolo Capris; Choroidal Abnormalities in Neurofimomatosis type 1 detected by Near-Infrared Reflectance Imaging in paediatric population. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4490.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract 
 
Purpose
 

To investigate choroidal abnormalities in paediatric patients with neurofibromatosis type 1 (NF1) detected by near-infrared reflectance (NIR) retinography in order to evaluate diagnostic accuracy.

 
Methods
 

Prospective case-control study. Seventy-eight paediatric patients with NF1, diagnosed according to the National Institutes of Health (NIH) criteria, and 96 healthy control subjects matched for age were examined. Enrolled patients were under 14 years old. The presence and the number of choroidal abnormalities were investigated by confocal scanning laser ophthalmoscopy.

 
Results
 

Seventy-eight patients with NF1 (41 female, 37 male; mean age 8.1±3.5 years), were compared with 96 healthy control subjects ( 42 female, 54 male; mean age 8±3 years). Choroidal abnormalities were observed in 53 (67.9%) of the NF1 patients. As regards the fundus topographical distribution, choroidal abnormalities were more frequent at the posterior pole with a statistically significant correlation between patient age and the number of involved choroidal areas. No choroidal abnormalities were present in the control group. Detection accuracy of choroidal nodules was 70%.

 
Conclusions
 

Choroidal abnormalities appearing as bright patchy regions detected by NIR imaging occurred very frequently in paediatric patients affected by NF1. The present study appears to show that NIR used to detect choroidal involvement allows for elevated diagnostic accuracy.

 
Keywords: 452 choroid • 550 imaging/image analysis: clinical  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×