April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Corneal sensitivity and inflammatory mediators in tears of asymptomatic and symptomatic hydrogel contact lens wearers
Author Affiliations & Notes
  • Maria-Jesus J. Gonzalez
    Ocular Surface Group, IOBA, University of Valladolid, Valladolid, Spain
    CIBER-BBN, Valladolid, Spain
  • Alberto López de la Rosa
    Ocular Surface Group, IOBA, University of Valladolid, Valladolid, Spain
    CIBER-BBN, Valladolid, Spain
  • Vicente Martín-Montañez
    Ocular Surface Group, IOBA, University of Valladolid, Valladolid, Spain
    CIBER-BBN, Valladolid, Spain
  • Alberto López-Miguel
    Ocular Surface Group, IOBA, University of Valladolid, Valladolid, Spain
    Vision I+D, Valladolid, Spain
  • Margarita Calonge
    Ocular Surface Group, IOBA, University of Valladolid, Valladolid, Spain
    CIBER-BBN, Valladolid, Spain
  • Amalia Enriquez-De-Salamanca
    Ocular Surface Group, IOBA, University of Valladolid, Valladolid, Spain
    CIBER-BBN, Valladolid, Spain
  • Footnotes
    Commercial Relationships Maria-Jesus Gonzalez, None; Alberto López de la Rosa, None; Vicente Martín-Montañez, None; Alberto López-Miguel, None; Margarita Calonge, None; Amalia Enriquez-De-Salamanca, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4664. doi:https://doi.org/
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    • Get Citation

      Maria-Jesus J. Gonzalez, Alberto López de la Rosa, Vicente Martín-Montañez, Alberto López-Miguel, Margarita Calonge, Amalia Enriquez-De-Salamanca; Corneal sensitivity and inflammatory mediators in tears of asymptomatic and symptomatic hydrogel contact lens wearers. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4664. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To analyze the differences in corneal sensitivity and in the tear levels of inflammatory molecules between symptomatic and asymptomatic hydrogel contact lens (HCL) wearers and its correlations.

Methods: Sixty-six subjects were included in the study: 47 HCL wearers, divided into asymptomatic (n=23) and symptomatic (n=24) by means of the Contact Lens Dry Eye Questionnaire (CLDEQ) and 19 non contact lens wearers (control group). Corneal sensitivity (mechanical and thermal -hot and cold- thresholds) was measured using Belmonte’s non invasive aesthesiometer. The following tear molecules: EGF, Fractalkine, Interleukin (IL)-10, IL-1β, IL-1RA, IL-2, IL-4, IL-6, IL-8, MCP-1, TNF-α and MMP-9 were evaluated in tears samples (collected by a microcapillar from the lower tear meniscus) by multiplex bead analysis in a Luminex IS-100. Ocular Surface Disease Index (OSDI) questionnaire (symptoms reported while subjects were wearing HCL) was also administered. Measures and samples were obtained after at least 24 hours of non HCL use. Outcomes were compared among symptomatic HCL, asymptomatic HCL and non HCL wearers, and correlations between measured variables for each group were analyzed.

Results: There were no significant differences among groups for any of the variables measured. The following significant correlations were found:1) in non HCL wearers group mechanical threshold correlated with: hot threshold (rho=-0.508, p<0.05), EGF (rho=0.626, p<0.01) and OSDI (rho=-0.656, p<0.01); hot threshold correlated with OSDI (rho=0.459, p<0.05) and cold threshold correlated with IL-8 (rho=-0.518, p<0.05); 2) in HCL wearers group (asymptomatic and symptomatic pooled) mechanical threshold correlated with hot threshold (rho=-0.311, p<0.05) and OSDI correlated with EGF (rho=-0.292, p<0.05); and 3) in asymptomatic HCL group OSDI correlated with EGF (rho=-0.497, p<0.05).

Conclusions: No significant differences in corneal sensitivity or the tear molecules concentrations among the study groups were found. It may indicate either that HCL wear does not have a meaningful effect on some of the parameters measured, or that ocular surface recovers from the effect caused by HCL during the first 24 hours. However, correlations found prove the relation between symptoms, corneal sensitivity and the expression of some tear molecules of these subjects.

Keywords: 477 contact lens • 565 innervation: sensation • 490 cytokines/chemokines  
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