April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Effect of environmental conditions in contact lens wearers
Author Affiliations & Notes
  • Vicente Martín-Montañez
    Ocular Surface Group, IOBA - University of Valladolid, Valladolid, Spain
    CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Valladolid, Spain
  • Alberto López-Miguel
    Ocular Surface Group, IOBA - University of Valladolid, Valladolid, Spain
    VISIÓN I+D, SL, Valladolid, Spain
  • Alberto López de la Rosa
    Ocular Surface Group, IOBA - University of Valladolid, Valladolid, Spain
    CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Valladolid, Spain
  • Itziar Fernández
    CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Valladolid, Spain
  • Margarita Calonge
    Ocular Surface Group, IOBA - University of Valladolid, Valladolid, Spain
    CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Valladolid, Spain
  • Jose Manuel Gonzalez-Meijome
    Clinical and Experimental Optometry Research Laboratory, Center of Physics, University of Minho, Braga, Portugal
  • Maria-Jesus J. Gonzalez
    Ocular Surface Group, IOBA - University of Valladolid, Valladolid, Spain
    CIBER-BBN (Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine), Valladolid, Spain
  • Footnotes
    Commercial Relationships Vicente Martín-Montañez, None; Alberto López-Miguel, None; Alberto López de la Rosa, None; Itziar Fernández, None; Margarita Calonge, None; Jose Manuel Gonzalez-Meijome, Coopervision (C); Maria-Jesus Gonzalez, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4669. doi:https://doi.org/
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      Vicente Martín-Montañez, Alberto López-Miguel, Alberto López de la Rosa, Itziar Fernández, Margarita Calonge, Jose Manuel Gonzalez-Meijome, Maria-Jesus J. Gonzalez; Effect of environmental conditions in contact lens wearers. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4669. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the effects of two environmental conditions, recreated within an environmental chamber, in hydrogel (Hy) and silicone-hydrogel (Si-Hy) contact lens (CL) wearers.

 
Methods
 

Fifty-four subjects were exposed to two environmental conditions: standard (STA): 50% relative humidity (RH), 23°C and 930 mb of pressure (P); and adverse (ADV): 5% RH, 23°C, 750 mb (P) and air flow. Subjects were bilaterally fitted with Hy (Omafilcon A -OMA-) and Si-Hy CL (Comfilcon A -COM-) and were exposed for 90 minutes to each environment in four different visits. Changes in comfort, dryness, blurred vision, visual acuity, osmolarity, NIBUT, phenol red thread test, bulbar and limbal hyperemia, limbal conjunctival and corneal staining and CL dehydration were assessed.

 
Results
 

Comfort decreased (p≤0.05) for OMA-STA (pre: 7.81±1.7, post: 7.4±1.7), COM-STA: (pre: 8.45±1.31, post: 7.32±1.99), OMA-ADV (pre: 7.96±1.75, post: 7.22±2.07) and COM-ADV (pre: 8.56±1.48, post: 7.44±1.82). Dryness increased (p≤0.05) for OMA-STA (pre: 2.2±2.23, post: 3.09±2.49), COM-STA (pre: 1.74±1.96, post: 3.49±2.45), OMA-ADV (pre: 1.5±1.8, post: 3.52±2.47) and COM-ADV (pre: 1.37±1.46, post: 3.28±2.41). Blurred vision increased (p≤0.05) in COM-STA (pre: 1.08±1.55, post: 1.66±1.94) and COM-ADV (pre: 1.12±1.61, post: 1.6±1.97). Tear osmolarity decreased (p≤0.001) for OMA-STA (pre: 325.13±23.84, post: 319.72±16.12 mOsm/L) and COM-STA (pre: 325.41±21.46, post: 320.63±19.38 mOsm/L). NIBUT decreased (p≤0.005) in OMA-ADV (pre: 8.15±6.4 s, post: 6.4±2.24 s) and COM-ADV (pre: 7.06±3.06 s, post: 5.91±1.92 s). Dehydration of CL was 13.35±3.48% for OMA-STA, 21.11±2.73% for COM-STA, 15.27±3.37% for OMA-ADV and 22.7±3.36% for COM-ADV (p<0.0001). Hyperemia and staining results are expressed in Table 1.

 
Conclusions
 

Environmental chambers can be a useful tool to understand the adverse effects of environment, CL materials or their combined effects in the development of CL discomfort.

 
 
Table 1. Significant changes (difference of medians in a 0-4 degrees scale) after exposure. *p≤0.05, ** p≤0.0001
 
Table 1. Significant changes (difference of medians in a 0-4 degrees scale) after exposure. *p≤0.05, ** p≤0.0001
 
Keywords: 477 contact lens • 486 cornea: tears/tear film/dry eye  
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