April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Treatment of corneal ulcers in ocular surface inflammation
Author Affiliations & Notes
  • Didier Renault
    Laboratoires Théa, Clermont-Ferrand, France
  • Sihem Lazreg
    Private practice, Alger, Algeria
  • Frederic Chiambaretta
    CHU Clermont-Ferrand, Clermont-Ferrand, France
  • Footnotes
    Commercial Relationships Didier Renault, None; Sihem Lazreg, None; Frederic Chiambaretta, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4718. doi:https://doi.org/
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      Didier Renault, Sihem Lazreg, Frederic Chiambaretta; Treatment of corneal ulcers in ocular surface inflammation. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4718. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Severe ocular surface inflammation can be lead to different diseases and can cause severe corneal involvement

Methods: 5 cases of ocular surface inflammation with severe corneal ulcers resistant to conventional treatment , all treated with à new matrix therapy agent (cacicol ) 1 drop a day every other day for 4 weeks , with biomicroscopic records at D0 , D3, D7, D 15 and D30.

Results: Patients were aged between 18 to 66 years old, ocular surface inflammation was due to GVHD, severe Sjögren's Syndrome, Atopic keratoconjuctivitis, ocular pymphygoide and Stevens Johnson syndrome, all ulcers were chronic and rebels to different treatment ,at D7 we observed a decrease on VAs pain scale at D15 in all cases a total epitheliazitation of the ulcers.

Conclusions: CACICOL is a new ophthalmic device, derived from RGTA based matrix therapy (large biopolymers engineered to replace heparan sulfates) , wich is a revolution in treatment of chronic ulcers, in our cases it has a double effect antalgic and regenerating.

Keywords: 482 cornea: epithelium  
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