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Luis Arroyo, David Arturo Ancona Lezama, Priscila Perez Peñaloza, Valeria Sanchez Huerta; Collagen cross linking as an adjuvant therapy in infectious corneal ulcers. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4724.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of cross linking as an adjuvant therapy in refractory infectious corneal ulcers
Anterior segment optical coherence tomography was performed in patients with confirmed infectious corneal ulcer by culture. 21 patients were included in which directed treatment after 2 weeks proved ineffective, and whose corneal ulcer thickness was greater than 400 microns. Drops of riboflavin 0.1% were administered every 5 minutes during a 15 minute period. A 9 mm beam of ultraviolet light (375 nm, 3mW/cm3) was then applied to the corneal surface for 25 minutes with the application of riboflavin drops at 5 minute intervals. Therapeutic contact lens was used afterwards plus previous antimicrobial therapy, and topical prednisolone acetate for a week.
Full epithelialization of the ulcer was achieved in 16 patients by the course of 2 weeks post therapy. 2 patients had delayed epithelialization by 4 weeks. 3 patients underwent conjunctival patch surgery due to corneal thinning.
Cross linking therapy can be effective in the treatment of infectious corneal ulcers refractory or not to medical treatment.
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