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Xiulan Zhang, Wenbin Huang, Minwen Zhou, Wei Wang, Xinbo Gao, Zheng Li; Is increased choroidal thickness a risk factor for Angle-closure?. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4727.
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Our previous studies using enhanced depth imaging optical coherence tomography (EDI-OCT) indicated that a higher level of macular choroidal thickness occurs in acute primary angle closure (APAC) eyes than in primary angle closure suspect (PACS) eyes and that choroidal thickness was thicker in APAC and PACS eyes than in normal control eyes. In the present study, we measured the choroidal thickness in the subtypes of angle-closure disease (except for APAC) to further research whether increased choroidal thickness is a risk factor for angle-closure disease.
162 angle-closure patients [including 71 PACS, 35 primary angle closure (PAC), and 56 primary angle closure glaucoma (PACG)] and 87 normal participants were examined. EDI-OCT was used to measure and to compare the macular choroidal thickness between the angle-closure eyes and normal eyes. The association between choroidal thickness and angle-closure eyes was analyzed.
The angle-closure eyes had a thicker choroid than the control eyes at all macular locations (all P <0.05). It remained significantly thicker after controlling for age, axial length (AL), and gender, except at 1 mm, 3 mm superior, and 3 mm nasal from the fovea. Univariate analysis showed that the subfoveal choroidal thickness (SFCT) was significantly associated with angle-closure eyes. After adjustment for the anterior chamber depth (ACD), vitreous chamber depth (VCD), and lens thickness (LT), the SFCT was still significantly associated with angle-closure eyes. The odds ratio (OR) was 1.008 (95% CI, 1.003-1.014). Most macular locations choroidal thickness had the positive associated with angle-closure eyes. The area under the curve (AUC) for detecting angle-closure eyes was 0.619 with SFCT, and the result was statistically significant (P = 0.002).
Angle-closure eyes have a higher level of macular choroidal thickness than normal eyes. Increased choroidal thickness is a risk factor for angle-closure disease. However, it had only low specificity for SFCT in screening for angle-closure disease.
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