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Gao Xinbo, Wenbin Huang, Wei Wang, Minwen Zhou, Xiulan Zhang, Xiulan Zhang study group; Topographic Profile of choroid in eyes after Acute Primary Angle-Closure. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4729.
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To explore and compare the topographic profile of choroid in eyes after suffering acute primary angle closure (APAC) with age- and sex-matched normal controls, and the relationship between choroidal thickness (CT) with ocular parameters and clinical features also be evaluated.
Enhanced depth imaging-optical coherence tomography (EDI-OCT) was used to scan choroidal topographic profile linearly for the thickness of locations distributed in the macular region. The average choroidal thickness was compared among each location separately in APAC group and control group, and between same locations of the two groups. Pearson correlation and Stepwise Multiple Regression Analysis were used to analyze the factors associated with CT, including IOP decreased level and duration of APAC.
The study included 44 participants with unilateral APAC affected eyes and 70 normal control eyes. Variants of choroidal thickness among macular locations were found in both groups. It was greatest at the subfovea and spread thinner around, reaching significant difference at 3 mm away in all quadrants except superior. This distribution of topographic profile was symmetry between the two groups while APAC has a thicker choroid profile at each location (P <0.005). Multivariable linear regression analysis showed that the subfoveal choroidal thickness (SFCT) was significantly thicker in association with the APAC diagnosis and longer axial length and older age. Duration time and IOP decreased level were not associated with the subfoveal choroidal thickness in one week after APAC.
APAC eyes have a higher level of macular choroidal thickness than normal eyes but share a symmetry variant distribution of choroidal topographic profile. Meanwhile, duration time and IOP decreased level in one week after onset of APAC have no influence on SFCT. SFCT may be an independently anatomical risk factor for APAC.
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