April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
The change of macular ganglion cell complex thickness in preperimetric glaucoma and normal eyes
Author Affiliations & Notes
  • Daisuke Shiba
    Ophthalmology, Keio University, Shinjuku-ku, Japan
    Iidabashi Eye Clinic, Tokyo, Japan
  • Takeshi Ono
    Ophthalmology, Keio University, Shinjuku-ku, Japan
    Iidabashi Eye Clinic, Tokyo, Japan
  • Naoki Ozeki
    Ophthalmology, Keio University, Shinjuku-ku, Japan
    Iidabashi Eye Clinic, Tokyo, Japan
  • Kenya Yuki
    Ophthalmology, Keio University, Shinjuku-ku, Japan
    Iidabashi Eye Clinic, Tokyo, Japan
  • Kazuo Tsubota
    Ophthalmology, Keio University, Shinjuku-ku, Japan
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4753. doi:
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      Daisuke Shiba, Takeshi Ono, Naoki Ozeki, Kenya Yuki, Kazuo Tsubota; The change of macular ganglion cell complex thickness in preperimetric glaucoma and normal eyes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4753.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the changes of the macular ganglion cell complex (GCC) thickness measured by spectral-domain optical coherence tomography (SD-OCT) between preperimetric glaucoma (PPG) eyes and normal eyes.

Methods: We retrospectively enrolled PPG and normal eyes with five or more times of SD-OCT examination as routine clinical practice. If both eyes were eligible, one eye was randomly selected. In SD-OCT examination, we measured mean macular GCC thicknesses within superior semicircle (SSC) and inferior semicircle (ISC) of 10-degree radius whose center was placed at fovea. The velocity of GCC thickness change by linear regression was calculated by the built-in software. We compared the velocities of mean GCC thicknesses in SSC and ISC between PPG and normal eyes by unpaired-t test.

Results: Twenty-seven PPG eyes (27 subjects) and thirty normal eyes (30 subjects) were enrolled to this retrospective study. The mean ages of PPG eyes and normal eyes were 51.6±11.0 and 54.9±13.3, respectively. Mean SSC GCC thickness in PPG and normal were 100.1±6.0 μm and 91.3±7.6 μm, respectively. Mean ISC GCC thickness in PPG and normal were 91.3±7.6 μm and 101.1±6.3 μm, respectively. The velocities of GCC thickness in SSC were -0.78 ±0.90 μm/year in PPG eyes and 0.05 ±0.80 μm/year in normal eyes (P < 0.001). The velocities of macular GCC thickness in ISC were -0.76 ±0.87 μm/year in PPG group and 0.04 ±0.40 μm/year in control group (P < 0.001).

Conclusions: Macular GCC thickness reduction rate in PPG eyes was higher than that in normal eyes.

Keywords: 550 imaging/image analysis: clinical • 459 clinical (human) or epidemiologic studies: biostatistics/epidemiology methodology  
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