April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Age and Race Variations in Human Optic Nerve Head (ONH) Structures in OCT Images using Bruch’s Membrane Opening or Peripapillary Scleral Opening as Reference Planes
Author Affiliations & Notes
  • Brandon Smith
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • John Johnstone
    Computer & Information Sciences, University of Alabama at Birmingham, Birmingham, AL
  • Massimo Antonio Fazio
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Lan Wang
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Michael J A Girard
    Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore
    Singapore Eye Research Institute, Singapore, Singapore
  • Jean M Mari
    Department of Medical Physics and Bioengineering, University College London, London, United Kingdom
  • Christopher A Girkin
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • Footnotes
    Commercial Relationships Brandon Smith, None; John Johnstone, None; Massimo Fazio, None; Lan Wang, None; Michael Girard, Singapore Ministry of Education, Academic Research Fund, Tier 1 (F); Jean Mari, None; Christopher Girkin, Heidelberg Engineering (F), SOLX (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4760. doi:
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    • Get Citation

      Brandon Smith, John Johnstone, Massimo Antonio Fazio, Lan Wang, Michael J A Girard, Jean M Mari, Christopher A Girkin; Age and Race Variations in Human Optic Nerve Head (ONH) Structures in OCT Images using Bruch’s Membrane Opening or Peripapillary Scleral Opening as Reference Planes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4760.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine variations in human ONH structures associated with age and race (African descent or AD; European descent or ED) with OCT images using either Bruch’s membrane opening (BMO) or peripapillary scleral opening (PSO) as reference planes.

 
Methods
 

This study included 166 OCT ONH volumes from normal healthy subjects (64 AD subjects, 102 ED subjects). Adaptive compensation was applied to all volumes to enhance the visibility of ONH tissue structures (Girard, Mari, et al., IOVS 2013). Anatomic structures were delineated in 12 of the 48 radial B-scans in each OCT volume using Devers Eye Institute Multiview custom software to develop 3D reconstructions. A best-fitting plane was computed using principal component analysis to define BMO and PSO, which were used as anatomic measurement reference planes. Using a uniform sampling grid we computed the mean and max distances from the BMO and PSO reference planes to the anterior lamina cribrosa (LC) surface (distance defined as the LC depth or LCD) and to the internal limiting membrane (ILM) (distance defined as the cup depth or CD). Mixed effects models were used to measure structural variations associated with race, age, axial length and age/race interactions. The BMO and PSO reference plane results were then compared.

 
Results
 

Consistent results (Table 1) were found using either BMO or PSO as reference planes. Specifically, variation in LCD and CD were both independently associated with age and race. Significant reduction in LCD was observed with advancing age in ED eyes. Subjects of AD had significantly greater deepening of LCD and CD compared to the ED group. There was a significant interaction between race and age in LCD and CD; with increasing age in AD subjects, LCD and CD increased. Significant reduction in max CD was seen with advancing age in ED eyes. Axial length was not a significant variable in any measurement and was not included in the final model.

 
Conclusions
 

Consistent measurements of deep ONH tissue structures were produced using as separate reference planes, BMO position and PSO position. There were no significant differences in LCD and CD measurements using the two reference planes. Determining a stable reference plane is critical in the quantification of ONH parameters.

  
Keywords: 550 imaging/image analysis: clinical • 629 optic nerve • 473 computational modeling  
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