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Athmar Dhahir Habeeb, Alastair Lockwood, Ali A Hussain, Jin H Wang, Mike Driver, Steve Brocchini, Peng Khaw; Developing phosphotidyl choline polymers for ocular implantation. Invest. Ophthalmol. Vis. Sci. 2014;55(13):477.
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Biocompatible hydrogels can be used as coatings to improve the biocompatibility of implantable devices. Hydrophilic hydrogels such as phosphotidyl choline (PC) co-polymers display decreased cell attachment compared to silicon and polystyrene, and are widely used in contact lens. We have characterized the physicochemical characteristics of different PC hydrogels as potential coating materials for ocular implantation.
PC hydrogel films were prepared by free radical polymerisation using varying amounts of methacrylate phosphotidyl choline (MPC), hydroxyethyl methacrylate (HEMA) and a cross link reagent. Polymerization were conducted in moulds to yield films for analysis and the polymerisation conditions were also varied (e.g. temperature, time). The resulting hydrogel films were characterized by calculating their degree of swelling, water content, water permeability, flexibility and the internal pore size.
Increasing the ratio of MPC to HEMA lead to increase in total water content and degree of swelling in the hydrogel films. Environmental SEM analysis indicated that increasing the polymerization time yielded films with smaller pores and lower water permeability.
Variation in the polymerization conditions lead to significant difference in the physical properties of the prepared hydrogel films which is likely to affect their biocompatibility. This is clinically relevant to their use in different ocular devices.
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