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Rachid Tahiri Joutei Hassani, Hong Liang, Mohamed El Sanharawi, Emmanuelle Brasnu, Sofiene Kallel, Antoine Labbe, Christophe Baudouin; En face spectral domain optical coherence tomography: a novel tool for anterior segment imaging. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4869.
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© ARVO (1962-2015); The Authors (2016-present)
To explore the potential of en face optical coherence tomography for the imaging of anterior segment diseases and to correlate the findings with conventional B-scans and in vivo confocal microscopy (IVCM) images.
In this observational case series, 140 eyes of 90 subjects with various anterior diseases were investigated with anterior-segment en face spectral-domain OCT between January and June 2013. The correlations between en face OCT images, biomicroscopy, conventional B-scans and IVCM were analyzed.
The diseases evaluated included pterygium, conjunctivochalasis, corneal deposits, dry eye keratitis, peripheral sterile infiltrates and infectious keratitis. En face OCT images showed anterior segment changes that were not discernible using conventional B-scans OCT. There was a good correlation with IVCM analysis. Compared with IVCM, the major advantages of en-face OCT included easy operation and rapid image acquisition, with minimal experience required. In addition, the non-contact method prevented patient discomfort and external pressure on the globe, which was especially useful in patients with corneal ulcers or infectious keratitis. Although the resolution of en-face OCT was lower than that of IVCM, it allowed useful overall visualization of corneal lesions due to the larger areas analyzed.
En-face SD-OCT is a novel, interesting tool to assess a wide variety of anterior segment conditions. Without corneal contact, it can provide additional information and new insight into different ocular surface conditions. With continued improvements in its technology, future development of en-face ultra-high-resolution (UHR) OCT will certainly improve resolution and enhance the sensitivity and specificity of this new technology, allowing earlier diagnosis and more reliable follow-up.
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