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Michael Hood, Eric J Sigler, Jorge I Calzada, John Randolph, Austin P Bell; Retinal Angiomatous Proliferation and Retinal-Choroidal Anastomosis in Childhood Coats Disease. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4971.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the structural features of retinal angiomatous proliferation and chorioretinal anastomosis in childhood Coats disease.
A prospective observational case series of consecutive patients presenting with Coats’ disease over a one year period was performed. Multimodal imaging, including color fundus photography, wide-field fluorescein angiography, and spectral-domain optical coherence tomography (SD-OCT) was used to identify the features of macular retinal angiomatous proliferation and chorioretinal anastomosis observed in patients with macular fibrosis.
5 of the 21 patients with Coats disease showed distinct characteristics consistent with retinal angiomatous proliferation and chorioretinal anastomosis on color photography, fluorescein angiography, and spectral-domain OCT with doppler enhancement. The lesions appeared as well-demarcated, nodular, retinal pigment epithelial detachments surrounded by exudate, with retinal vessels continuous with the underlying choroidal neovascularization.
Retinal angiomatous proliferation and chorioretinal anastomoses are common features observed in children with Coats disease. This lesion likely underlies the previous “macular fibrosis” and “subretinal mounds” previously described, and represents a distinct macular variant of Coats disease.
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