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Lisa Nawei Chen, Voraporn Chaikitmongkol, Adam S Wenick, Susan B Bressler, Neil M Bressler; Reading Functions in One Eye versus Both Eyes Open in Neovascular Age-related Macular Degeneration and Their Associations with Patient Reported Vision-related Function Using NEI VFQ-25. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4986. doi: https://doi.org/.
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To compare reading in the "better-" or "faster-reading" eye compared with both eyes open among patients with neovascular age-related macular degeneration (AMD).
A convenient cohort being managed for neovascular AMD in at least one eye were enrolled after informed consent approved by an institutional review board if visual acuity was 20/200 or better in at least one eye. Visual acuity by ETDRS charts, reading acuity and maximum reading speed by MNRead charts, and reading speed with large type reading charts were measured with each eye alone and then with both eyes. The “better-reading” eye was defined as an eye that read ≥0.2 logMAR than the other eye if either eye read ≥0.7 logMAR, or read ≥0.1 logMAR than the other eye if both eyes read ≤0.6 logMAR. The “faster-reading” eye was defined as an eye that read ≥15 words per minute more than the other eye. Patient-reported vision-related function was measured using the National Eye Institute Vision Function Questionnaire-25 (NEI VFQ-25). Correlations were assessed using Pearson correlation.
Among 41 neovascular AMD subjects (82 eyes), mean age was 80±10 years; 68% were women. On average, the left eye read 1.4±5 Snellen lines (7±25 ETDRS letters) better than the right eye. Both eyes open showed better reading acuity than the “better-reading” eye in 22% (95% confidence interval [CI]: 9% to 40%), and worse reading acuity in 22% (95% CI: 9% to 40%). Both eyes open read at a faster maximum reading speed than the “faster-reading” eye in 13% (95% CI: 3% to 29%), and slower in 19% (95% CI: 7% to 36%). When using large type reading charts, both eyes open read faster than the “faster-reading” eye in 13% (95% CI: 4% to 27%), and slower in 23% (95% CI: 11% to 39%). The correlation of the NEI VFQ-25 near activity subscale score with reading acuity when both eyes were open was -0.568 (95% CI: -0.745 to 0.315, P<0.001), -0.610 (95% CI: -0.793 to -0.326, P<0.001) with the “better-reading” eye reading acuity, and 0.559 (95% CI: 0.092 to 0.632, P=0.001) with the “faster-reading” eye maximum reading speed.
Reading acuity and reading speed measured using only the "better-" or "faster-reading" eye appears to be better compared with both eyes open in some patients with neovascular AMD, but worse in others.
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