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Jens F Kiilgaard, Mette Bagger, Morten T Andersen, Steffen Heegaard, Mette K Andersen; The correlation between survival and AJCC staging and genetic status in uveal melanoma patients. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5080.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the predictive value of genetic status and AJCC Staging in patients with uveal melanoma.
Patient charts for patients treated during 2009 and 2012 were reviewed. Information on survival, AJCC stage and Chromosomal status were collected.
A total number of 151 patients with either Ciliary or choroidal melanoma were treated at Copenhagen University Hospital between 1 jan 2009 and 31 dec 2012. in 12 cases no genetic information were found. 27.5% of the patients had a normal chromosome status. Normal chromosomal status was found in 9 of 26 stage 1, 28 of 91 stage 2, 4 of 32 stage 3 and 0 of 2 stage 4 patients. A overall survival rate of 63 % after 4 years were observed. Only 1 melanoma related death was observed in the group with normal chromosomal status. There was a direct correlation between AJCC staging and death and number of abnormal chromosomes and death. A combination of AJCC staging and chromosomal status gave the best prediction of melanoma related death.
AJCC staging and chromosomal status are good predictors of survival. For prediction of melanoma related death a combination of AJCC staging and chromosomal status gave the best results
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