The correlation between survival and AJCC staging and genetic status in uveal melanoma patients

Abstract

 

Purpose

 

To evaluate the predictive value of genetic status and AJCC Staging in patients with uveal melanoma.

 

Methods

 

Patient charts for patients treated during 2009 and 2012 were reviewed. Information on survival, AJCC stage and Chromosomal status were collected.

 

Results

 

A total number of 151 patients with either Ciliary or choroidal melanoma were treated at Copenhagen University Hospital between 1 jan 2009 and 31 dec 2012. in 12 cases no genetic information were found. 27.5% of the patients had a normal chromosome status. Normal chromosomal status was found in 9 of 26 stage 1, 28 of 91 stage 2, 4 of 32 stage 3 and 0 of 2 stage 4 patients. A overall survival rate of 63 % after 4 years were observed. Only 1 melanoma related death was observed in the group with normal chromosomal status. There was a direct correlation between AJCC staging and death and number of abnormal chromosomes and death. A combination of AJCC staging and chromosomal status gave the best prediction of melanoma related death.

 

Conclusions

 

AJCC staging and chromosomal status are good predictors of survival. For prediction of melanoma related death a combination of AJCC staging and chromosomal status gave the best results

 

 

Keywords: 589 melanoma • 744 tumors • 745 uvea