April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
EDI-OCT for early evaluation of recurrence after ruthenium brachitherapy for choroidal melanoma
Author Affiliations & Notes
  • Monica M. Pagliara
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Maria Grazie Sammarco
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Francesca Leonardi
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Andrea Scupola
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Caputo G Carmela
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Aldo Caporossi
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Maria Antonietta Blasi
    Department of Ophthalmology, Catholic University of the Sacred Heart, Rome, Italy
  • Footnotes
    Commercial Relationships Monica Pagliara, None; Maria Grazie Sammarco, None; Francesca Leonardi, None; Andrea Scupola, None; Caputo Carmela, None; Aldo Caporossi, None; Maria Antonietta Blasi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5088. doi:https://doi.org/
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      Monica M. Pagliara, Maria Grazie Sammarco, Francesca Leonardi, Andrea Scupola, Caputo G Carmela, Aldo Caporossi, Maria Antonietta Blasi; EDI-OCT for early evaluation of recurrence after ruthenium brachitherapy for choroidal melanoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5088. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the use of EDI-OCT and ultrasonography for early detection of marginal recurrence in posterior uveal melanoma treated with brachitherapy.

Methods: recently available EDI-OCT has allowed to detect early recurrences of uveal melanoma after brachytherapy in 3 eyes of 3 patients (1 male and 2 female). Inclusion criteria were: posterior pole localization and rapidly regression to a flat scar. Every 4 months, all patients underwent complete follow-up visit including fundus examination, fundus photography (Panoret) , ultrasonography and EDI using SD OCT with the Heidelberg Spectralis (Heidelberg Engineering , Heidelberg. Germany).

Results: in these patients, EDI-OCT was able to confirm recurrences already detected by ultrasonography, however the improved resolution of EDI-OCT allowed a more precise measurements of these lesions. In addition, EDI-OCT pointed out other small marginal nodules deemed undetectable by ultrasonography.

Conclusions: EDI-OCT is particularly useful in identifying small posterior tumors as its axial resolution is approximately 3 to 4 µm compared with 10 µm for time-domain OCT and approximately 50 to 200 µm for ultrasonography, as reported in literature. Furthermore, in our study EDI-OCT documented its ability to located small recurrences before ultrasonography detection. In selected cases EDI-OCT proved to be a valid non invasive tool for monitoring uveal melanoma treated with brachytherapy.

Keywords: 624 oncology • 589 melanoma • 671 radiation therapy  
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