April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Relationship between Pattern electroretinogram, Frequency Domain-OCT and Automated perimetry in Chronic papilledema from Pseudotumor Cerebri Syndrome
Author Affiliations & Notes
  • Clara Lima Afonso
    OPHTHALMOLOGY, UNIVERSITY OF SAO PAULO, Sao Paulo, Brazil
  • Maria K Oyamada
    OPHTHALMOLOGY, UNIVERSITY OF SAO PAULO, Sao Paulo, Brazil
  • Kenzo Hokazono
    OPHTHALMOLOGY, UNIVERSITY OF SAO PAULO, Sao Paulo, Brazil
  • Mario L R Monteiro
    OPHTHALMOLOGY, UNIVERSITY OF SAO PAULO, Sao Paulo, Brazil
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5101. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Clara Lima Afonso, Maria K Oyamada, Kenzo Hokazono, Mario L R Monteiro; Relationship between Pattern electroretinogram, Frequency Domain-OCT and Automated perimetry in Chronic papilledema from Pseudotumor Cerebri Syndrome. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5101.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To evaluate the ability of transient pattern electroretinogram (PERG) parameters to differentiate between eyes with visual field (VF) loss and resolved papilledema from pseudotumor cerebri syndrome (PTC) and controls, to compare PERG and OCT with regard to discrimination ability, and to assess the correlation between PERG, FD-OCT and VF measurements.

Methods: VFs and full-field stimulation PERGs based on both 48 and 14-min checks were obtained from patients with PTC (n=24, 40 eyes) and controls (n=22, 26 eyes). In addition, FD-OCT peripapillary retinal nerve fiber layer (RNFL) and segmented macular layer measurements were obtained and their correlation coefficients were determined.

Results: Compared to controls, PERG N95 and the P50+N95 amplitude measurements with 48-min checks were significantly reduced in eyes with resolved papilledema from PTC. Both PERG N95 amplitude and OCT parameters were able to discriminate papilledema eyes from controls although the macular thickness parameters were more efficient at detecting abnormalities. Significant correlations were found between PERG amplitude values and OCT-measured macular ganglion cell layer and RNFL thickness and total retinal thickness. PERG amplitude was also significantly associated with VF sensitivity loss.

Conclusions: PERG measurements were able to detect neural loss in PTC eyes with a performance comparable to OCT. PERG amplitude measurements were reasonably well correlated with OCT-measured parameters.

Keywords: 613 neuro-ophthalmology: optic nerve • 507 electrophysiology: clinical • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×