April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Macular cone photoreceptor density distribution in fellow eyes of young adults
Author Affiliations & Notes
  • Tianjiao Zhang
    Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL
    Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL
  • Pooja Godara
    Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL
  • Russell Griffin
    Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL
  • Ernesto Blanco
    Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL
    Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL
  • Xiaolin Wang
    Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL
  • Christine A Curcio
    Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL
  • Yuhua Zhang
    Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL
    Department of Ophthalmology, The University of Alabama at Birmingham, Birmingham, AL
  • Footnotes
    Commercial Relationships Tianjiao Zhang, None; Pooja Godara, None; Russell Griffin, None; Ernesto Blanco, None; Xiaolin Wang, None; Christine Curcio, None; Yuhua Zhang, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5129. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Tianjiao Zhang, Pooja Godara, Russell Griffin, Ernesto Blanco, Xiaolin Wang, Christine A Curcio, Yuhua Zhang; Macular cone photoreceptor density distribution in fellow eyes of young adults. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5129. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

Quantitative estimation of cone packing density distribution in fellow eyes of young subjects with good retinal health may provide a baseline for understanding age- or disease-related cone loss. We examine macular cone photoreceptor density differences in fellow eyes using adaptive optics scanning laser ophthalmoscopy (AOSLO).

 
Methods
 

Twenty subjects aged 19-29 years were enrolled. All subjects underwent assessment of best-corrected visual acuity and measurement of refractive error to ensure no participant had refractive errors worse than -3 D or fellow-eye refractive error difference greater than 0.25 D. The retinal magnification factor for each subject was calculated using the Liou and Brennan eye model with the corneal curvature, anterior chamber depth, and axial length of the eyes measured using an ocular biometer. AOSLO was performed to image the maculae. Cone density was assessed over the central 2400 µm x 2400 µm macula, and evaluated statistically with a mixed model approach. Each eye was divided into four quadrants: superior/nasal (SN), superior/temporal (ST), inferior/nasal (IN), and inferior/temporal (IT). Within each quadrant, the association between cone density and eccentricity was compared between fellow eyes. A three-way interaction term was included in models to examine whether the association between eyes and cone density by eccentricity varied by quadrant.

 
Results
 

The isodensity lines of macular cone density of fellow eyes have the same shapes (Fig.1). There was no difference in the association between eccentricity and cone density in fellow eyes for the quadrants SN (p=0.8503), ST (p=0.1551), IN (p=0.8609), and IT (p=0.6662). Associations did not vary between quadrants (p=0.6772). In all subjects, the maximum cone density difference [assessed by (DOS-DOD)/DOD] at a single sample point was 23.6%, and the root-mean-square difference was 6.78%.

 
Conclusions
 

We have characterized the macular cone density distribution in fellow eyes including the fovea in 2 dimensions, and estimated the maximum and average cone density differences. Overall, macular cone distributions in fellow eyes are radially and bilaterally symmetric, but considerable difference may exist at single points. The range of differences is consistent with data previously reported by Lombardo et al. for the parafoveal horizontal meridian.

 
 
Figure 1. Macular cone density distribution in subject 84. Plots are centered on the fovea.
 
Figure 1. Macular cone density distribution in subject 84. Plots are centered on the fovea.
 
Keywords: 648 photoreceptors • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 688 retina  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×