April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Predictive factors on spectral domain optical coherence tomography in neovascular age-related macular degeneration.
Author Affiliations & Notes
  • Serena Fragiotta
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Alessandro Cutini
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Leopoldo Spadea
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Vittoria De Rosa
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Pier Luigi Grenga
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Mariella Salomone
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Enzo M Vingolo
    Department of Medical and Surgical Science and Biotechnology, UOC Ophthalmology, University of Rome "Sapienza"- Pontine Pole, Latina, Italy
  • Footnotes
    Commercial Relationships Serena Fragiotta, None; Alessandro Cutini, None; Leopoldo Spadea, None; Vittoria De Rosa, None; Pier Luigi Grenga, None; Mariella Salomone, None; Enzo Vingolo, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5210. doi:https://doi.org/
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      Serena Fragiotta, Alessandro Cutini, Leopoldo Spadea, Vittoria De Rosa, Pier Luigi Grenga, Mariella Salomone, Enzo M Vingolo; Predictive factors on spectral domain optical coherence tomography in neovascular age-related macular degeneration.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5210. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: to investigate risk factors predictive for the development of neovascular age-related macular degeneration (NVAMD) with spectral domain optical coherence tomography (SD-OCT).

Methods: Fifty eyes of 50 age-sex matched patients with stage 2 and 3 of the International grading system for age related macular degeneration (AMD) and a minimum follow-up of 24 months (mean follow-up time: 32.85±11.36 months) were retrospectively collected. During follow-up 25 eyes developed in NVAMD. Drusenoid pigment epithelial detachment (DPED), hyperreflective foci (HRF), integrity of external limiting membrane (ELM), inner segment ellipsoid portion/outer segment (IS/OS), RPE/Bruch’s membrane complex (RPE/B) and subfoveal choroidal thickness (CT) were analyzed at baseline and last follow-up (FUL). Odds ratio (OR) for neovascular lesion was calculated.

Results: Mean CT was significantly thinner in NVAMD group at baseline (P=0.01) and at FUL (P=0.02). The presence of reticular pseudodrusen was not significant between groups (P=0.16). Lesions with HRF (OR, 18; 95% confidence interval [CI], 2.83-81.09), discontinuity of RPE/B (OR, 15.16; 95% CI, 1.92-167.98), and ELM (OR, 24.37; 95% CI, 3.82-155.45) were significant predictors of new onset NVAMD at FUL (progression time: 6.35±2.66 months). Also the discontinuity of IS/OS showed a positive association with NVAMD (OR, 3.40; 95% CI, 1.62-7.10). Although the presence of DPED was not significant (OR, 1.55; 95% CI, 0.11-20.61), the width of DPED was significantly larger in NVAMD than control group both at baseline (P=0.001) and FUL (P<0.001).

Conclusions: The presence of HRF and the integrity of RPE/B and ELM bands seems to be predictive factors of NVAMD. Moreover mean subfoveal CT was significantly thinner in NVAMD group than control group. CT may integrated the stratification of NVAMD progression risk. These findings provide important information about the natural history of choroidal neovascularization.

Keywords: 412 age-related macular degeneration • 453 choroid: neovascularization • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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