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Lala Ceklic, Sebastian Wolf, Aljoscha S Neubauer, Hannan Abdillahi, Ute E Schnurrbusch-Wolf; Reticular pseudodrusen on ultrawidefield autofluorescence and color scanning laser imaging. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5223.
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Reticular pseudodrusen (RPD) are considered to be linked to an increased risk of choroidal neovascularisation and progression of geographic atrophy (GA) in patients with age related macular degeneration (AMD). Little is known on the distribution over the RPD based on different imaging technologies, which therefore was the reason we investigated RPD using a ultra-wide field scanning laser ophthalmoscope.
We included 167 eyes from 167 patients >50 years diagnosed with wet AMD in this prospective case series. All patients underwent FAF, OCT (Heidelberg Engineering) and ultra wide field imaging with an ultra wide field scanning laser system (Optos P200Tx) at the University Eye Clinic Inselspital, Bern, Switzerland. Ultra-wide field Autofluorescence (FAF) and pseudocolor (CF) images based on red and green channel were evaluated individually and RPD detection and distribution were compared.
RPD was detected in 68 (40%) of the patients. Detection rate was low for FAF (26 eyes) and red channel (12 eyes). Green channel showed highest detection rate (56 eyes). Most frequently RPD were seen in green channel in med peripheral superonasal (82%), superotemporal (78%), inferiornasal (57%) and inferiortemporal (53%). Far peripheral location of RPD seen in green channel mode was: superonasal (69%), superotemporal (61%), inferiortemporal (21%) and inferiornasal (13%)
RPD are better detected with green channel images versus red channel and autofluorescence. RPD show a characteristic tendency to disperse to the fundus periphery. Green light technology could obtain promising results in early recognition and subsequent follow up of this disease.
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