April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Comparison of standardized color photography grading and SDOCT volume analysis for quantitative assessment of drusen and geographic atrophy in intermediate age-related macular degeneration
Author Affiliations & Notes
  • Vincent Tai
    Ophthalmology, Duke University Eye Center, Durham, NC
  • Francisco A Folgar
    Ophthalmology, Duke University Eye Center, Durham, NC
  • Monica B Sevilla
    Ophthalmology, Duke University Eye Center, Durham, NC
  • Traci E Clemons
    Statistics, Emmes Corporation, Rockville, MD
  • Ronald P Danis
    Ophthalmology and Visual Science, University of Wisconsin-Madison, Madison, WI
  • Emily Y Chew
    Epidemiology & Clinical Applications, National Eye Inst/NIH, Bethesda, MD
  • Sina Farsiu
    Ophthalmology, Duke University Eye Center, Durham, NC
  • Cynthia A Toth
    Ophthalmology, Duke University Eye Center, Durham, NC
  • Footnotes
    Commercial Relationships Vincent Tai, None; Francisco Folgar, None; Monica Sevilla, None; Traci Clemons, None; Ronald Danis, None; Emily Chew, None; Sina Farsiu, NIH 1R01EY022691 (research) (F); Cynthia Toth, Alcon (research) (F), Bioptigen (research) (F), Genentech (research) (F), NIH 1R01EY023039 (research) (F), Physical Sciences Inc. (research) (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5225. doi:
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      Vincent Tai, Francisco A Folgar, Monica B Sevilla, Traci E Clemons, Ronald P Danis, Emily Y Chew, Sina Farsiu, Cynthia A Toth; Comparison of standardized color photography grading and SDOCT volume analysis for quantitative assessment of drusen and geographic atrophy in intermediate age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5225.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine correlation of color fundus photography (CFP) macular surface area grading of drusen and geographic atrophy (GA) with spectral domain optical coherence tomography (SDOCT) volume analysis of drusen and retinal pigment epithelium abnormal thinning (RAT).

 
Methods
 

Eyes with intermediate age-related macular degeneration (AMD) were enrolled in the prospective Age-Related Eye Disease Study 2 (AREDS2) Ancillary SDOCT Study. After semi-automated SDOCT segmentation, macular volumes for drusen and RAT were calculated based on a normative SDOCT database of 115 healthy age-controlled eyes. Baseline volumes were correlated with same-visit AREDS2 CFP grading of drusen area score (scale 0-7) by Kruskal-Wallis analysis and CFP grading of GA disc areas by Spearman rank correlation (ρ).

 
Results
 

265 intermediate AMD eyes with baseline CFP and SDOCT analysis were included. On CFP, mean (± standard deviation) drusen area score was 6.1 ± 1.1 (non-linear measurement of mean drusen area was 1.17 ± 0.66 mm2) and mean GA area was 0.11 ± 0.50 disc areas (non-linear measurement of mean GA area was 0.19 ± 0.88 mm2). On SDOCT analysis, mean drusen volume was 0.084 ± 0.160 mm3 and mean RAT volume was 0.8 ± 2.1x10-3 mm3. Greater CFP drusen score was associated with greater drusen volume (p<0.001), although each score had wide variance in SDOCT drusen volume. CFP GA area directly correlated with SDOCT RAT volume (ρ=0.40, p<0.001). 240 eyes (91%) had zero GA area, whereas 9 eyes (3%) had zero RAT volume.

 
Conclusions
 

SDOCT measurements of drusen and RAT volumes correlated significantly with CFP drusen score and GA areas, respectively. In intermediate AMD, SDOCT drusen and RAT volumes provide novel measurements of subretinal pigment epithelium deposits and atrophic changes, respectively.

 
Keywords: 412 age-related macular degeneration • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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