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Vincent Tai, Francisco A Folgar, Monica B Sevilla, Traci E Clemons, Ronald P Danis, Emily Y Chew, Sina Farsiu, Cynthia A Toth; Comparison of standardized color photography grading and SDOCT volume analysis for quantitative assessment of drusen and geographic atrophy in intermediate age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5225.
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© ARVO (1962-2015); The Authors (2016-present)
To determine correlation of color fundus photography (CFP) macular surface area grading of drusen and geographic atrophy (GA) with spectral domain optical coherence tomography (SDOCT) volume analysis of drusen and retinal pigment epithelium abnormal thinning (RAT).
Eyes with intermediate age-related macular degeneration (AMD) were enrolled in the prospective Age-Related Eye Disease Study 2 (AREDS2) Ancillary SDOCT Study. After semi-automated SDOCT segmentation, macular volumes for drusen and RAT were calculated based on a normative SDOCT database of 115 healthy age-controlled eyes. Baseline volumes were correlated with same-visit AREDS2 CFP grading of drusen area score (scale 0-7) by Kruskal-Wallis analysis and CFP grading of GA disc areas by Spearman rank correlation (ρ).
265 intermediate AMD eyes with baseline CFP and SDOCT analysis were included. On CFP, mean (± standard deviation) drusen area score was 6.1 ± 1.1 (non-linear measurement of mean drusen area was 1.17 ± 0.66 mm2) and mean GA area was 0.11 ± 0.50 disc areas (non-linear measurement of mean GA area was 0.19 ± 0.88 mm2). On SDOCT analysis, mean drusen volume was 0.084 ± 0.160 mm3 and mean RAT volume was 0.8 ± 2.1x10-3 mm3. Greater CFP drusen score was associated with greater drusen volume (p<0.001), although each score had wide variance in SDOCT drusen volume. CFP GA area directly correlated with SDOCT RAT volume (ρ=0.40, p<0.001). 240 eyes (91%) had zero GA area, whereas 9 eyes (3%) had zero RAT volume.
SDOCT measurements of drusen and RAT volumes correlated significantly with CFP drusen score and GA areas, respectively. In intermediate AMD, SDOCT drusen and RAT volumes provide novel measurements of subretinal pigment epithelium deposits and atrophic changes, respectively.
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