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Arnaud Sauer, Odile Villard, Christophe Chiquet, Catherine P Garcher, Ermanno Candolfi, Tristan Bourcier; Intraocular levels of IL-17A and IL-10 as determinant markers of respectively toxoplasmis and viral uveitis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5279.
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Uveitis is a potentially blinding inflammatory disease affecting individuals of any age. Despite huge advances in diagnostic techniques, many cases of uveitis remain idiopathic. Specific CD4+ T helper (Th) cell-mediated immune responses and cytokines are increasingly being considered to play a central role in the pathogenesis of uveitis. The aim of the present study was to determine the intraocular cytokines patterns in various causes of uveitis, in order to bring better comprehension of the immunological regulation of uveitis and to determine whether cytokine pattern may be an interesting diagnosis tool.
In a prospective multicenter study, we used multiplex assay to study the profiles of 27 cytokines and chemokines in aqueous humor samples from patients with various etiology of uveitis, determined after a complete biological and clinical work-up, by comparison with control group of patients with cataract.
Sixty-two patients with infectious or non-infectious uveitis and 88 controls were included. After a complete work-up, cause of uveitis remains unknown for 25 patients (40% idiopathic uveitis). Level of IL-1β was notably increased in viral uveitis, IL-10 also in viral uveitis and IL-17A in toxoplasmic uveitis. Using this cytokines particularity, patients were reaffected in specific groups. Endly, only 11 patients (18%) remain with the diagnosis of idiopathic uveitis.
The fact that some markers are specific to certain diseases is of major interest because it allows a better understanding of the pathogenesis of these disorders. Moreover, it paves the way for new diagnostic methods in identifying inflammatory markers whose elevation is specific to certain etiology, as it is the case for ocular lymphoma, and maybe also to targeted therapy.
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