April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Serum 25-hydroxy-Vitamin D Levels and Diabetic Retinopathy in a Multi-ethnic Asian Population
Author Affiliations & Notes
  • Mohammad Kamran Ikram
    Singapore Eye Research Institute, Singapore, Singapore
    Department of Ophthalmology, National University of Singapore, Singapore, Singapore
  • Gavin Tan
    Singapore Eye Research Institute, Singapore, Singapore
  • Charumathi Sabanayagam
    Singapore Eye Research Institute, Singapore, Singapore
  • Kumari Neelam
    Singapore Eye Research Institute, Singapore, Singapore
  • Ecosse Luc Lamoureux
    Singapore Eye Research Institute, Singapore, Singapore
  • E SHyong Tai
    Singapore Eye Research Institute, Singapore, Singapore
  • Paul Mitchell
    Singapore Eye Research Institute, Singapore, Singapore
  • Jie Jin Wang
    Singapore Eye Research Institute, Singapore, Singapore
  • Ching-Yu Cheng
    Singapore Eye Research Institute, Singapore, Singapore
  • Tien Y Wong
    Singapore Eye Research Institute, Singapore, Singapore
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5346. doi:
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      Mohammad Kamran Ikram, Gavin Tan, Charumathi Sabanayagam, Kumari Neelam, Ecosse Luc Lamoureux, E SHyong Tai, Paul Mitchell, Jie Jin Wang, Ching-Yu Cheng, Tien Y Wong; Serum 25-hydroxy-Vitamin D Levels and Diabetic Retinopathy in a Multi-ethnic Asian Population. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5346.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Low levels of 25-hydroxyvitamine D (Vit D) have been implicated in diabetes and its microvascular complications, including diabetic retinopathy (DR). However, data from Asian populations are lacking. In the current study we examined the association between 25-Vit D and DR in a multi-ethnic Asian population.

Methods: A nested case-control design study was conducted using data from three population-based cohorts: Singapore Chinese Eye Study (SCES), Singapore Malay Eye Study (SiMES) and Singapore Indian Eye Study (SINDI). All subjects underwent a comprehensive eye examination including retinal photography, and blood samples were collected. Diabetes was defined as casual plasma glucose ≥200mg/dl (11.1mmol/l), glycosylated hemoglobin (HbA1c) levels ≥6.5%, self-reported physician-diagnosed diabetes, or the use of glucose lowering medication. Retinal photographs, taken from both eyes, were graded for the presence and severity of DR using the modified Airlie House classification system. A total of 695 controls (persons with diabetes, but without DR) and 328 cases (patients with DR) were selected for the present analyses. Serum levels of 25-Vit D and parathyroid hormone were measured using samples stored at baseline.

Results: The mean age of this sample was 67.8 years (standard deviation: 8.1), of whom 47.3% were women. The mean serum levels of 25-Vit D were 20.0ug/l in the cases and 21.7ug/l in the controls (unadjusted p-value = 0.02). However, in multivariate logistic regression models adjusted for age, sex, body mass index, blood pressure, duration of diabetes and parathyroid hormone levels, 25-Vit D levels were not associated with the presence of DR [odds ratio: 0.97; 95% confidence interval: 0.82-1.14].

Conclusions: In the current study, levels of 25-hydroxy-vitamine D were not associated with the presence of DR in a multi-ethnic Asian population.

Keywords: 464 clinical (human) or epidemiologic studies: risk factor assessment • 499 diabetic retinopathy  
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