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Ahmad Samir AlFaar, Mohamed S Bakry, Sameera Ezzat; Childhood Orbital, Ocular and Optic nerve tumors in Egypt. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5427.
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© ARVO (1962-2015); The Authors (2016-present)
Our aim is to study the incidence of different ocular, orbital and optic nerve tumors in childhood age group (between 0-18 years old) in the largest Egyptian pediatric oncology referral center and correlate the features of each disease and its survival outcomes.
Institutional cancer registry database was reviewed for patients who presented with orbital tumors as a primary site of involvement between July 2007 and November 2013. REDCap (Research Electronic Data Capture) system was used for data collection and organization. Integration between clinical information system and RedCap was established for real-time registry updating. Relevant ICD-O-3 topography codes were used to identify the sites. Data were presented in terms of frequencies and percentages. Other demographic properties were presented. Survival was demonstrated using kaplan-meier curves.
Among 7277 patients presented with different childhood tumors 425 had the mentioned lesions. Males were affected more than females. Retinoblastoma, Astrocytomas of optic nerve and Rhabdomyosarcoma of orbit were the most frequent tumors. Mean age of retinoblastoma cases was 1.4 years while it was higher in other diseases except germ cell tumors. We've presented correlations of our findings with the current Egyptian population-based cancer registry and previous results from Cancer in five continents report. Overall Survival of Retinoblastoma was 95.4% while it was better in Germ cell tumors and less in all other tumor categories. Orbital bones masses were hard to identify due to the broad classification in current ICD-O topography coding.
Childhood orbital tumors distribution was similar to international publications except increased incidence of orbital lymphomas. Special attention should be paid to updating the ICD-O classification system to present different skull bones.
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