April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Prognostication in Ocular Adnexal Lymphoma - Feasibility of the Latest Tumour, Tode, Metastasis Staging System
Peter Rasmussen; Sarah E Coupland; Paul T Finger; Enrique O Graue; Hans E Grossniklaus; Penny McKelvie; Kaustubh Mulay; Jan Ulrik Prause; Elisabeth Ralfkiaer; Steffen Heegaard
Author Affiliations & Notes
  • Peter Rasmussen
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark
  • Sarah E Coupland
    Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, Liverpool, United Kingdom
  • Paul T Finger
    Department of Ocular Oncology, The New York Eye Cancer Center, New York City, NY
  • Enrique O Graue
    Department of Ocular Oncology, The New York Eye Cancer Center, New York City, NY
  • Hans E Grossniklaus
    Emory Eye Center, Section of Ocular Oncology, Emery University, Atlanta, GA
  • Penny McKelvie
    The Orbital Plastic and Lacrimal Clinic, The Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia
  • Kaustubh Mulay
    Prasat Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India
  • Jan Ulrik Prause
    Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark
  • Elisabeth Ralfkiaer
    Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
  • Steffen Heegaard
    Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Eye Pathology Institute, University of Copenhagen, Copenhagen, Denmark
  • Footnotes
    Commercial Relationships Peter Rasmussen, None; Sarah Coupland, None; Paul Finger, None; Enrique Graue, None; Hans Grossniklaus, None; Penny McKelvie, None; Kaustubh Mulay, None; Jan Ulrik Prause, None; Elisabeth Ralfkiaer, None; Steffen Heegaard, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5442. doi:
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      Peter Rasmussen, Sarah E Coupland, Paul T Finger, Enrique O Graue, Hans E Grossniklaus, Penny McKelvie, Kaustubh Mulay, Jan Ulrik Prause, Elisabeth Ralfkiaer, Steffen Heegaard; Prognostication in Ocular Adnexal Lymphoma - Feasibility of the Latest Tumour, Tode, Metastasis Staging System. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5442.

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Abstract

Purpose: To evaluate the prognostic utility of the tumour, node, metastasis (TNM)-based staging system for primary ocular adnexal lymphomas (i.e. lymphomas arising in the orbit, the eyelids, the conjunctiva, the lacrimal gland and the lacrimal sac) proposed by the American Joint Committee on Cancer.

Methods: Retrospective, multicenter study of patients with primary ocular adnexal lymphoma collected from six eye-cancer centers from January 1st 1980 through December 31st 2010.

Results: A total of 578 eligible patients were included in the study, 293 (51%) were females. The median age was 61 years (range 3 - 97 years). The most frequent lymphoma subtypes were: extranodal marginal zone lymphoma (397/578, 69%), follicular lymphoma (63/578, 11%), and diffuse large B-cell lymphoma (52/578, 9%). The TNM-stages were: T1N0M0/conjunctiva (23%), T2N0M0/orbit including the lacrimal gland (67%), T3N0M0/eyelid (6%) and T4N0M0/extension beyond the orbit (2%). For the entire study group the 5-year survival was 73%. The group of patients with diffuse large B-cell lymphoma had a significantly poorer survival compared with extranodal marginal zone lymphoma and follicular lymphoma (5-year survival, 31% vs. 79% vs. 81%, respectively) (log-rank p < 0.01). The survival was not associated with the extension or site-specific location of the lesions as depicted by the TNM-based stages in any of the lymphoma subtypes.

Conclusions: Lymphoma arising in the ocular adnexal region is mainly prevalent in elderly patients. The survival is primarily determined by histopathology rather tumour size or site-specific location.

Keywords: 624 oncology • 744 tumors • 638 pathology: human  
© 2014, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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