Purchase this article with an account.
Gerd Geerling, Marc Schargus, Adrian Gericke, Ursula Schlotzer-Schrehardt, Walter Lisch; Peripheral hypertrophic subepithelial corneal opacification. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5459.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To describe bilateral corneal changes in form of limbus parallel circumscribed opacifications .
34 patients matching clinical diagnostic criteria were included. 5 patients were treated by superficial keratectomy due to irregular astigmatism induced by the peripheral opacifications. Excised tissues were studied by light and electron microscopy.
All patients were white and all but seven were female. The age range of the study population was 23-83 years, the median age 50 years. There are no other ophthalmologic irregularities or associated systemic abnormalities and no indication of drug-induced keratopathy. The peripheral corneal opacities were whitish-grey, circumscribed,and partially elevated. Sometimes a mild vascularization of the lesion. All of the female patients showed a bright iris. Follow-up mean period was 35 months with no or minimal progression of the corneal changes. Histologically, diffuse subepithelial hyalinosis and focal degenerations of the overlying epithelium were seen.
The etiology of this new entity is unknown. DNA analysis should be performed to in-or exclude a own corneal dystrophy. We also recommend a hormone assay of the female patients including the period of the oral contraceptive use.
This PDF is available to Subscribers Only