April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Epidemiology of Ulcerative Keratitis: Bronx Experience
Author Affiliations & Notes
  • Susan Huang
    Ophthalmology, Albert Einstein / Montefiore Medical Center, Bronx, NY
  • Alessa Crossan
    Ophthalmology, Albert Einstein / Montefiore Medical Center, Bronx, NY
  • Grace Honik
    Ophthalmology, Albert Einstein / Montefiore Medical Center, Bronx, NY
  • David C Gritz
    Ophthalmology, Albert Einstein / Montefiore Medical Center, Bronx, NY
  • Footnotes
    Commercial Relationships Susan Huang, None; Alessa Crossan, None; Grace Honik, None; David Gritz, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5467. doi:
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      Susan Huang, Alessa Crossan, Grace Honik, David C Gritz; Epidemiology of Ulcerative Keratitis: Bronx Experience. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5467.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To identify the epidemiological characteristics, predisposing factors, and the microbiological diagnosis of ulcerative keratitis in Bronx, New York.

Methods: A retrospective review of medical records with diagnosis coding for corneal ulcers during a three-year period between January 1, 2010 and December 31, 2012 was performed. Inclusion criteria were new diagnosis of ulcerative keratitis during the study period; diagnosis defined as a corneal epithelial defect with stromal inflammatory infiltrate secondary to bacterial, fungal, or parasitic cause; home zip code in Bronx; positive corneal cultures or response to therapy and clinical course consistent with infectious ulcerative keratitis; no evidence of stromal infiltrates secondary to viral, immune-mediated, or rheumatologic causes.

Results: Of 351 cases with appropriate diagnosis coding, 120 patients met inclusion criteria. Ulcerative keratitis occurred with a mean age 41.8 with female predominance (53.3%). Most common ethnicities were Hispanic (39.2%), Black (30.8%), and Caucasian (14.2%). Most common predisposing risk factors were contact lens wear (51.7%), ocular surface disease (24.2%), previous ocular surgery (16.7%), and ocular trauma (14.2%). 5% cases were known HIV-positive. Positive cultures for Gram-positive and Gram-negative species yielded similar occurrence rate (50%, 50%), with coagulase-negative staphylococci as the most common Gram-positive isolate (20%) and Pseudomonas as the most common Gram-negative isolate (34%). Pseudomonas made up 66.7% of contact lens-related cases.

Conclusions: Ulcerative keratitis in this cohort from the Bronx more likely affected women, often due to contact lens use. There is a high predominance of Pseudomonas, especially with contact lens-related cases. This study offers insight into the epidemiology of ulcerative keratitis in an urban setting and contributes to the limited literature of HIV association with ulcerative keratitis.

Keywords: 463 clinical (human) or epidemiologic studies: prevalence/incidence • 479 cornea: clinical science • 477 contact lens  

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