Purpose
To assess the 24-hour IOP lowering effect of unoprostone isopropyl ophthalmic solution (UIOS) 0.15% dosed BID.
Methods
We enrolled 10 subjects with either POAG or ocular hypertension who had untreated IOPs ≥ 23 mm Hg and <32 mm Hg in at least one eye. Technicians administered one drop of UIOS 0.15% at 6 am and 10 pm daily for three days. While the patient was in the sitting position, IOP was measured using Goldmann tonometry; at the same time points, a Perkins tonometer was used to measure IOP with the patient supine. We measured IOP in both the supine and seated positions at Baseline and on Day 3 at the following time points: 0.75, 2, 4, 6, 10, 14, 18, and 22 hours after the 6 am dose.
Results
The mean age of the subjects was 70.5 years. On Day 3, the mean change in 24-hour diurnal IOP from Baseline in the sitting position was 4.7±1.0 mm Hg (p<0.001). Overall, after three days of BID dosing, IOP reduction measured in the sitting position appears uniform and relatively flat over 24-hours. Mean change in nighttime IOP, assessed in the sitting position after the second daily-dose, is also statistically significantly lower post-treatment versus baseline (p<0.001). On Day 3, the mean change in 24-hour diurnal IOP from Baseline in the supine position was 4.2±0.8 mm Hg (p<0.001). Overall, after three days of dosing twice daily, IOP reduction measured in the supine position appears relatively flat over 24-hours. Mean change in nighttime IOP, assessed in the supine position after the second daily-dose, is also statistically significantly lower post-treatment versus baseline (p<0.001).
Conclusions
In this study, after three days of dosing, the 24-hour IOP curves of patients treated with unoprostone isopropyl 0.15% ophthalmic solution appear to be relatively flat and suggest around the clock efficacy with BID dosing. The IOP reduction was greater during the day than at night.
Keywords: 568 intraocular pressure •
633 outflow: trabecular meshwork