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Jean-Paul G Renard, Jean Marie Giraud, Nischal Aryal-Charles, Hussam El Chehab, Franck May, Christophe Chiquet, Jean Paul Romanet, Florent Aptel; Progression of visual field in patients with ocular hypertension and primary open-angle glaucoma:PROG-F study1 Preliminary results. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5618.
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To evaluate the visual field rate of progression of patients with treated ocular hypertension (OHT) and primary-open angle glaucoma (POAG).
From a multicentric database, 441 eyes of 228 patients with treated ocular hypertension or POAG followed up at least 6 years with Humphrey 24.2 Sita-Standard visual field examination at least twice a year were identified. From initial data, eyes were classified in 5 groups: 104 ocular hypertension, 205 early glaucoma (MD>-6dB), 45 moderate glaucoma (MD -6 to -12dB), 41 advanced glaucoma (MD -12 to -18dB) and 46 severe glaucoma (MD<-18dB). Rate of progression during the follow-up period was calculated using the trend analysis of the Guided Progression Analysis software.
The mean duration of follow-up was 8.4 years. We found a significant positive association between initial MD and rate of progression in early, moderate and advanced glaucoma (p<0.04). Rate of progression was -0.06 dB/year (-0.19 %VFI/year) in eyes with ocular hypertension, -0.24 dB/year (-0.75 %VFI/year) in eyes with early glaucoma, -0.45 dB/year (-1.72 %VFI/year) in moderate glaucoma, -0.54 dB/year (-2.44 %VFI/year) in advanced glaucoma, and -0.45 dB/year (-1.97 %VFI/year) in severe glaucoma.
In early to advanced stages of glaucoma, the rate of progression worsened as the severity increased, but became smaller in latest stage of the disease.
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