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Arielle R Spitze, Andrew J Tatham, Peter Rosen, Linda M Zangwill, Robert N Weinreb, Michelle A Sato, Erwin R Boer, Felipe A Medeiros; The relationship between frequency doubling technology (FDT) perimetry and useful field of view (UFOV) testing in glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5648.
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© ARVO (1962-2015); The Authors (2016-present)
Frequency doubling technology (FDT) has been proposed as a perimetric test for the diagnosis of glaucoma, targeting the magnocellular pathway. This pathway is thought to process information about the location and movement of objects and also to be associated with spatial attention processing. The Useful Field of View (UFOV) is a binocular test able to assess processing speed under a divided attention task, which has been shown to be predictive of driving ability in older adults. The purpose of this study was to evaluate the ability of FDT to predict UFOV results and to compare it to that of conventional standard automated perimetry (SAP).
This was a cross-sectional study including both eyes of 75 subjects with glaucoma, 181 subjects suspected of having glaucoma, and 57 healthy subjects. All subjects were recruited from the Diagnostic Innovations in Glaucoma Study (DIGS). All subjects had Matrix FDT, SAP, and UFOV testing within 3 months. Glaucoma was defined based on the presence of glaucomatous optic neuropathy on masked assessment of stereophotographs. The relationships between UFOV results (log of divided attention time) and mean sensitivities (in decibels) for FDT and SAP were examined with linear regression models adjusting for age.
The mean age of included subjects was 60 ± 16 years. Mean FDT sensitivity values in the better eye were 23.8 ± 3.8 dB, 26.2 ± 4.0 dB, and 28.3 ± 2.8 dB in glaucoma, suspects, and healthy subjects, respectively. Corresponding values for SAP were 28.5 ± 2.1 dB, 30 ± 2.3 dB and 31.4 ± 1.1 dB, respectively. Lower sensitivity values for the better eye on FDT perimetry were significantly associated with slower UFOV divided attention results (P<0.001). However, the ability of FDT perimetry to predict UFOV results was not significantly different than that of SAP (adjusted R2 of 19% and 22%, respectively, for multivariable models adjusting for age). Similar results were obtained when the worse eye was considered.
There was a statistically significant relationship between FDT results and UFOV measurements of processing speed under divided attention. However, the ability of FDT perimetry to predict UFOV results was not significantly better than that of conventional SAP.
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