Abstract
Purpose:
To examine the relation between GCIPT, measured by optical coherence tomography (OCT) and visual function, in RRMS eyes.
Methods:
Cirrus OCT, mfVEP and Pelli-Robson contrast sensitivity (CS) were obtained from 90 RRMS patients. One eye from each was randomly selected for analysis (37 eyes with last optic neuritis (ON) ≥6 months and 53 no-ON eyes). mfVEP, recorded with 60-sector cortically-scaled dartboard pattern-reversal stimulus (22° radius, VERIS 5.1), provided local response amplitude (logSNR) and latency (ms). Global and central 5.6° mfVEP amplitude and latency were calculated as mean logSNR (or median SNR) and median latency from all 60 and central 24 sectors, respectively.[1] 76 eyes had Humphrey visual field (HVF) 24-2 or 30-2; 23 eyes had HVF 10-2. Relative visual sensitivity (RVS) was calculated as average unlogged local deviation. Traditional pattern-reversal VEP (tVEP) was recorded in 30 patients (22° radius stimulus); p100 amplitude and latency measured. Pearson correlation was assessed between structural measures, GCIPT and average retinal nerve fiber layer thickness (RNFLT), and functional measures.
Results:
Both ON and no-ON eyes showed significant structure-function correlations, ON higher. For all eyes, among functional measures, GCIPT showed the highest correlation with mfVEP central 5.6° logSNR (r=0.72 p<0.0001; r=0.63 for SNR, p<0.0001) followed by CS (r=0.63, p<0.0001). GCIPT showed moderate correlation with 10-2 RVS (r=0.49, p=0.03) but no correlation with tVEP amplitude. RNFLT showed moderate to good correlation with mfVEP global logSNR (r=0.55, p<0.0001), CS (r=0.63, p<0.0001), weak correlation with 24-2/30-2 RVS (r=0.23, p=0.05) and no correlation with tVEP amplitude. GCIPT also showed good correlation with mfVEP central 5.6° latency (r=0.48, p<0.0001) and tVEP latency (r=0.69, 0.68, 0.48 for 15’, 60’, 120’ checks, p<0.0001).
Conclusions:
GCIPT correlated well with mfVEP amplitude and latency. GCIPT and mfVEP provide useful structural and functional measures of macular ganglion cells in RRMS. 1. Hood and Greenstein Prog Retin Eye Res 22: 201-251, 2003
Keywords: 759 visual impairment: neuro-ophthalmological disease •
507 electrophysiology: clinical •
613 neuro-ophthalmology: optic nerve