April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal pigment epithelium striations in Vogt-Koyanagi-Harada disease: A new biomarker for visual prognosis
Author Affiliations & Notes
  • Kouhei Hashizume
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Yutaka Imamura
    Ophthalmology, Teikyo University School of Medicine, Mizonokuchi Hospital, Kawasaki, Japan
  • Takamitsu Fujiwara
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Shigeki Machida
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Masahiro Ishida
    Ophthalmology, Teikyo University School of Medicine, Mizonokuchi Hospital, Kawasaki, Japan
  • Daijiro Kurosaka
    Ophthalmology, Iwate Medical University, Morioka, Japan
  • Footnotes
    Commercial Relationships Kouhei Hashizume, None; Yutaka Imamura, None; Takamitsu Fujiwara, None; Shigeki Machida, None; Masahiro Ishida, None; Daijiro Kurosaka, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5802. doi:https://doi.org/
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    • Get Citation

      Kouhei Hashizume, Yutaka Imamura, Takamitsu Fujiwara, Shigeki Machida, Masahiro Ishida, Daijiro Kurosaka; Retinal pigment epithelium striations in Vogt-Koyanagi-Harada disease: A new biomarker for visual prognosis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5802. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate the clinical significance of retinal pigment epithelium (RPE) striations in the acute stage of Vogt-Koyanagi-Harada disease.

 
Methods
 

RPE striations in eyes with acute VKH were detected using EDI-OCT and classified into 4 grading scales (grade 1: no striation, grade 2: small striations, grade 3: middle striatiosn, grade 4: large striations) by 2 independent examiners. The relation between clinical characteristics and grading of RPE striations was investigated.

 
Results
 

Among 47 eyes of 24 patients with acute VKH (mean age: 50 years), 32 (68 %) eyes showed RPE striations; grade 1: 15 (32 %) eyes, grade 2: 8 (17 %) eyes, grade 3: 13 (28 %), and grade 4: 11 (23 %) respectively. The patients with RPE striations in either eye were older at onset (p < 0.001) and longer duration of subjective visual disturbance at first visit (p < 0.05) than those without striations. The eyes with RPE striations showed larger choroidal thickness before high-dose steroid therapy (p < 0.01). Multiple regression analysis revealed that grading scores of RPE striations were independent predictor of frequent posterior recurrences (p < 0.05) and poor visual acuity at final visit (p < 0.05).

 
Conclusions
 

RPE striations detected by EDI-OCT are relatively frequent in the acute stage of VKH, and strong RPE striations appear to be a possible risk factor of posterior recurrence and poor visual acuity after high-dose steroid therapy.

  
Keywords: 746 uveitis-clinical/animal model • 452 choroid • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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