April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Author Affiliations & Notes
  • Noriyasu Hashida
    Dept of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
  • Kohji Nishida
    Dept of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5810. doi:
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      Noriyasu Hashida, Kohji Nishida; ANTERIOR-SEGMENT OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN EYES WITH SCLERITIS. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5810.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To study the use of anterior-segment optical coherence tomography (AS-OCT) for measuring the status of inflamed sclera and the scleral thickness in patients with scleritis.

Methods: In this prospective study, we recruited 20 consecutive eyes of ten patients (4 men, 6 women; mean age, 64.1 ± 12.1 years) with diffuse scleritis and 40 eyes of 20 healthy volunteers. The Osaka University Medical School Ethics Committee approved the study protocol, and all patients provided informed consent. The sclera was imaged 3 mm from the detected scleral spur using an AS-OCT system (VisanteTM-OCT, Carl Zeiss Meditec) and the “enhanced corneal high resolution” protocol, which is comprised of 512 A-scans (10-mm scan length and 3-mm scan depth). Two masked observers evaluated the scleral structures and thickness before and after treatment and compared the superior (90 degrees), nasal (0 degrees), inferior (270 degrees), and temporal (180 degrees) quadrants.

Results: The mean follow-up period was 7.9 ± 2.3 months. The mean scleral thickness of patients with scleritis before treatment was 0.70 ± 0.12 mm and that of normal healthy controls was 0.53 ± 0.08 mm, a difference that reached significance (p<0.001). Remission was achieved after treatment with topical and systemic steroids. The average scleral thickness in eyes with scleritis after treatment significantly (p<0.001) decreased to 0.50 ± 0.10 mm. In patients with necrotizing scleritis, the scleral thickness decreased markedly.

Conclusions: Patients with scleritis had a significant increase in scleral thickness compared with normal controls. AS-OCT allows visualization and reproducible measurements of the anterior segment and scleral thickness, providing a new paradigm for evaluating scleritis and its treatment.

Keywords: 746 uveitis-clinical/animal model • 550 imaging/image analysis: clinical • 421 anterior segment  

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