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Brendan Butler, Pablo Hernandez-Martinez, Isabel Pascual-Camps, Angélica de Freytas, Maria Andreu-Fenoll, Rosa Dolz-Marco, Jesse J Jung, Marcela Marsiglia, Sarah Mrejen, Roberto Gallego-Pinazo; Topographic Choroidal Thickness Analysis of the Macula by Swept Source Optical Coherence Tomography in Unilateral Multifocal Choroiditis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5813.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the choroidal thickness (CT) of the macular area in eyes with unilateral multifocal choroiditis (MFC) in the convalescent stage.
Consecutive cases with the diagnosis of MFC underwent a comprehensive ophthalmologic examination, best-corrected visual acuity (BCVA), color fundus and autofluorescence photographs, infrared reflectance imaging and swept-source optical coherence tomography. Automated segmentation of the retina and the choroid was used to obtain the corresponding thickness values, and an ETDRS sector grid was applied to compare the choroidal thickness of those sectors affected with choroidal neovascularization (CNV) and those without CNV.
Eleven patients (9 women) with a mean age of 31.77±11.75 were included. The mean±SD time from the onset of visual symptoms related to MFC was 28.9±13.1 months, with a mean of 20.1±10.3 months since the last inflammatory relapse. The mean BCVA was 0.91±0.16 in eyes with MFC and 0.99±0.03 in the fellow eyes (p=0.182). The mean foveal retinal central thickness measured 237.33+/-35.13 and 255.73±18.55 microns respectively (p=0.043); and the mean macular retinal thickness was 269.64±27.07 and 285.58±17.22 microns respectively (p=0.315). The mean subfoveal choroidal thickness was 206.33±41.96 and 234.10±45.95 microns respectively (p=0.190); and the mean macular choroidal thickness was 210.2±33.54 and 239.4±56.97 microns respectively (p=0.280). Areas affected with CNV in 9 of the 11 eyes with MFC did not show any significant difference with respect to areas without CNV in terms of mean choroidal thickness (212.50±27.22 versus 192.46±86.44, p=0.589)
In the present study, retinal and choroidal macular thicknesses were not significantly different between the affected eye and the unaffected fellow eye in patients with unilateral MFC; however, foveal retinal thickness was decreased in the eyes affected with MFC lesions. In addition, macular areas affected with secondary CNV did not show evidence of any significant difference in choroidal thickness when compared with those without CNV.
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