Purchase this article with an account.
Eleonore DIWO, Adil Darugar, Nathalie Massamba, Phuc Lehoang, Sam Razavi, Bahram Bodaghi; SS- OCT analysis of choroidal involvement in patients with uveitis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5814.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The aim of this clinical case series is to describe the choroid with swept-source OCT (SS-OCT) technology in patients with ocular inflammation and to determine possible signs of infra-clinical reactivation.
The charts of consecutive patients with intraocular inflammatory disorders, managed between may and june 2013 at Pitie-Salpetriere Hospital, have been reviewed. A choroidal map with SS-OCT, using 12-mm horizontal vertical scans through the macula was performed in all cases.
We included 20 patients with an average age of 55 years (40-84) and a M/F ratio of 0.82. Most of cases were posterior with 7 birdshot retinochoroidopathies (BRC), 3 Behçet's diseases (BD), 2 multifocal choroiditis (MFC), 1 Vogt-Koyanagi-Harada (VKH) disease, 1 acute syphilitic posterior placoid chorioretinitis, 2 ARN syndromes. Four anterior cases were also analyzed. The average choroidal thicknesss (CT) in active and inactive BRC was 280 µm and 247 µm, respectively with a maximum CT decrease of 30 µm immediately after therapeutic initiation. The lowest CT value of 194 µm was found in an advanced atrophic form of BRC associated with a discrete dashed line square. The average retinal thickness (RT) was decreased to 210 µm. CT and RT in 3 BD were decreased to 292 µm and 180 µm. Their low visual acuity was caused by a loss of IS/OS line. CT of the 2 ARN syndromes was decreased to 270 and 210 µm. The maximum CT difference between healthy and affected eyes was 110 µm. In 2 MFC, one patient had an increased CT of 307µm and one patient had a thin CT of 111µm with a minor dashed line square. In the VKH patient CT was unchanged in both eyes. There was a significant asymmetry in the patient with syphilitic placoid chorioretinitis, with a choroidal thickness of 334 µm in the affected eye vs 387 µm in the contralateral eye. CT was increased in a case of sarcoidosic intermediate uveitis while it was normal in cases of anterior uveitis.
Choroidal mapping shows increased CT compared to the controlateral unaffected eye and the same eye after anti-inflammatory treatment as a sign of activity in most cases of this series (BRC, BD or CMF). These cases may have a poor prognosis with further choroidal atrophy. A comparative prospective study of choroidal thickness before and after treatment may complete these preliminary findings.
This PDF is available to Subscribers Only