April 2014
Volume 55, Issue 13
ARVO Annual Meeting Abstract  |   April 2014
Plasma levels of PDGF-B in Patients with Neovascular AMD
Author Affiliations & Notes
  • Gerhard F. Kieselbach
    Medical University, Innsbruck, Austria
  • Claus Zehetner
    Medical University, Innsbruck, Austria
  • Rudolf Kirchmayr
    Medical University, Innsbruck, Austria
  • Martina T Kralinger
    Medical University, Innsbruck, Austria
  • Footnotes
    Commercial Relationships Gerhard Kieselbach, None; Claus Zehetner, None; Rudolf Kirchmayr, None; Martina Kralinger, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 582. doi:
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      Gerhard F. Kieselbach, Claus Zehetner, Rudolf Kirchmayr, Martina T Kralinger; Plasma levels of PDGF-B in Patients with Neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2014;55(13):582.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: To determine the plasma levels of PDGF-B, VEGF and TNF-α in patients with neovascular age-related macular degeneration (AMD)

Methods: 30 patients with neovascular AMD and 12 healthy controls were included in this prospective study. The concentrations of PDGF-B, VEGF and TNF- α were measured by ELISA.

Results: The PDGF-B concentration in the plasma of controls was [median (25-75 percentile)] 263.5 (162.0 - 513.3) pg/ml . In patients with neovascular AMD PDGF-B levels were significantly higher with a median plasma concentration of 783.5 (289.3 - 1183.5) pg/ml (p=0.003). The VEGF concentrations in patients with neovascular AMD 55.0 (37.0 - 116.3) pg/ml showed no significant differences (p=0.159). No significant differences of systemic TNF-α levels could be found between the study groups.

Conclusions: Patients with neovascular AMD have significantly higher plasma PDGF-B levels compared to healthy controls. Our study data provide further evidence for the possible importance of PDGF-B in the pathophysiology of neovascular AMD

Keywords: 412 age-related macular degeneration  

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