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Pedro Machado de Souza Leão, Leticia Fernandes Barroso, Rubens C Siqueira, Rodrigo Jorge; MULTIMODAL EVALUATION OF PATIENTS WITH CHRONIC CENTRAL SEROUS CHORIORETINOPATHY. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5866.
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© ARVO (1962-2015); The Authors (2016-present)
To describe differences between fluorescein (FA) and indocyanine green (ICG) angiography findings in patients with central serous chorioretinopathy (CSC).
Retrospective, observational study in which 10 consecutive patients with CSC underwent multimodal evaluation that included FA, ICG and optical coherence tomography (OCT) (Spectralis HRA-OCT, Heidelberg Engineering, Heidelberg, Germany). Changes such as hyperfluorescence (caused by transmission, staining or pooling) and hypofluorescence (caused by blockage or vascular filling defect) were evaluated in early (4 minutes), mid (4-8 minutes) and late (more than 8 minutes) angiography phases.
Seven of the 10 patients (19 eyes) were men, mean (± SD) patient age was 50.7 ± 8.4 years, and bilateral disease was present in 9 of the 10 patients. Areas of discontinuation or attenuation of the RPE hyperreflective layer on OCT, and transmission hyperfluorescence on FA and ICG occurred in coincident locations during the same examination phases. In areas of serous or RPE detachment, the hyperfluorescence pattern was also similar on FA compared to ICG. However, ICG demonstrated areas of hyperfluorescence secondary to choriocapillaris hyperpermeability with no corresponding change on FA in X (70%) of the 19 eyes. This ICG finding was more evident in the mid and late phases of the examinations and there was no evident change in retinal architecture in these choroidal hyperpermeable regions.
In patients with CSC, ICG may reveal choroidal abnormalities not evident on FA and OCT. This information may help to optimize the monitoring and treatment of CSC.
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