April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
The Effect of Photodynamic Therapy on Short-Wavelength Fundus Autofluorescence in Eyes with Acute Central Serous Chorioretinopathy
Author Affiliations & Notes
  • Stefan Hagen
    Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Clinic, Vienna, Austria
  • Siamak Ansari-Shahrezaei
    Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Clinic, Vienna, Austria
  • Eva Smretschnig
    Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Clinic, Vienna, Austria
  • Ilse Krebs
    Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Clinic, Vienna, Austria
  • Carl G O Glittenberg
    Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Clinic, Vienna, Austria
  • Susanne Binder
    Ophthalmology, Rudolf Foundation Clinic, Vienna, Austria
    Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Rudolf Foundation Clinic, Vienna, Austria
  • Footnotes
    Commercial Relationships Stefan Hagen, None; Siamak Ansari-Shahrezaei, None; Eva Smretschnig, None; Ilse Krebs, None; Carl Glittenberg, None; Susanne Binder, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5867. doi:
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      Stefan Hagen, Siamak Ansari-Shahrezaei, Eva Smretschnig, Ilse Krebs, Carl G O Glittenberg, Susanne Binder; The Effect of Photodynamic Therapy on Short-Wavelength Fundus Autofluorescence in Eyes with Acute Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5867.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To evaluate short-wavelength fundus autofluorescence (SW-FAF) as parameter of retinal pigmentepithelium (RPE) function in eyes with acute symptomatic central serous chorioretinopathy (CSC) after indocyanine green angiography (ICGA)-guided verteporfin (Visudyne®, Novartis Pharma, Switzerland) photodynamic therapy (PDT) with half-fluence rate.

Methods: A retrospective review over a period of six months of SW-FAF images of 15 consecutive patients treated with half-fluence rate (25J/cm2) ICGA-guided verteporfin PDT due to acute symptomatic CSC was performed. Short-wavelength (488nm) fundus autofluorescence grey values (SW-FAFGV) were evaluated with a confocal scanning laser ophthalmoscope (Heidelberg Engineering, Heidelberg, Germany) at a 350µm diameter and a 1200µm diameter circle centered on the fovea. The change in SW-FAFGV for the two circles was evaluated by calculating the differences of respective values between the first month after treatment and the 3 and 6 months follow-up respectively.

Results: Mean differences [95% CI] in SW-FAFGV of the 350µm and 1200µm diameter circle between the one month and the 3 months (n=15) follow up were -0.03 [-0.11; 0.05] (p=0.46) and -0.03 [-0.17; 0.099] (p=0.6). Respective differences between the one month and the 6 (n=15), months follow-up were -0.03 [-0.11; 0.05] (p=0.42) and -0.04 [-0.16; 0.08] (p=0.5);

Conclusions: Half-fluence rate (25J/cm2) ICGA-guided verteporfin PDT, did not significantly affect SW-FAF at a 350µm diameter and a 1200µm diameter circle in eyes with resolved acute symptomatic CSC throughout 6 months of follow-up.

Keywords: 688 retina • 701 retinal pigment epithelium  
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