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Stefan Hagen, Siamak Ansari-Shahrezaei, Eva Smretschnig, Ilse Krebs, Carl G O Glittenberg, Susanne Binder; The Effect of Photodynamic Therapy on Short-Wavelength Fundus Autofluorescence in Eyes with Acute Central Serous Chorioretinopathy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5867.
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To evaluate short-wavelength fundus autofluorescence (SW-FAF) as parameter of retinal pigmentepithelium (RPE) function in eyes with acute symptomatic central serous chorioretinopathy (CSC) after indocyanine green angiography (ICGA)-guided verteporfin (Visudyne®, Novartis Pharma, Switzerland) photodynamic therapy (PDT) with half-fluence rate.
A retrospective review over a period of six months of SW-FAF images of 15 consecutive patients treated with half-fluence rate (25J/cm2) ICGA-guided verteporfin PDT due to acute symptomatic CSC was performed. Short-wavelength (488nm) fundus autofluorescence grey values (SW-FAFGV) were evaluated with a confocal scanning laser ophthalmoscope (Heidelberg Engineering, Heidelberg, Germany) at a 350µm diameter and a 1200µm diameter circle centered on the fovea. The change in SW-FAFGV for the two circles was evaluated by calculating the differences of respective values between the first month after treatment and the 3 and 6 months follow-up respectively.
Mean differences [95% CI] in SW-FAFGV of the 350µm and 1200µm diameter circle between the one month and the 3 months (n=15) follow up were -0.03 [-0.11; 0.05] (p=0.46) and -0.03 [-0.17; 0.099] (p=0.6). Respective differences between the one month and the 6 (n=15), months follow-up were -0.03 [-0.11; 0.05] (p=0.42) and -0.04 [-0.16; 0.08] (p=0.5);
Half-fluence rate (25J/cm2) ICGA-guided verteporfin PDT, did not significantly affect SW-FAF at a 350µm diameter and a 1200µm diameter circle in eyes with resolved acute symptomatic CSC throughout 6 months of follow-up.
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