April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Outer Retinal Tubulation as a Predictor of the Growth Rate of Geographic Atrophy in Age-related Macular Degeneration
Author Affiliations & Notes
  • Amirhossein Hariri
    Doheny Eye Institute, Los Angeles, CA
  • Muneeswar G Nittala
    Doheny Eye Institute, Los Angeles, CA
  • Srinivas R Sadda
    Doheny Eye Institute, Los Angeles, CA
  • Eric C Strauss
    Genentech Inc., South San Francisco, CA
  • Phillip Lai
    Genentech Inc., South San Francisco, CA
  • Erin Henry
    Genentech Inc., South San Francisco, CA
  • Footnotes
    Commercial Relationships Amirhossein Hariri, None; Muneeswar Nittala, None; Srinivas Sadda, Allergan (C), Carl Zeiss Meditec (C), Genentech (C), Optos (C); Eric Strauss, Genentech (E); Phillip Lai, Genentech (E); Erin Henry, Genentech (E)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5885. doi:https://doi.org/
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      Amirhossein Hariri, Muneeswar G Nittala, Srinivas R Sadda, Eric C Strauss, Phillip Lai, Erin Henry; Outer Retinal Tubulation as a Predictor of the Growth Rate of Geographic Atrophy in Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5885. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine whether the presence of outer retinal tubulation (ORT) predicts the growth of geographic atrophy (GA) lesions in eyes with age-related macular degeneration (AMD).

 
Methods
 

The MAHALO study (NCT01229215) enrolled 143 subjects into a Phase Ib/II multicenter, randomized, single-masked, sham-injection controlled clinical trial of the safety, tolerability and evidence of activity of lampalizumab in patients with GA associated with AMD. Spectral domain optical coherence tomography (SD-OCT, Cirrus OCT) images were evaluated with baseline and Month 18 data of fellow (non-study) eyes for this exploratory analysis. Area of GA was automatically computed using the OCT instrument software and segmentation errors were manually corrected. The change in GA area between baseline and Month 18 was computed. In addition, baseline OCT volume scans were inspected for the presence of ORT. The GA growth rate (with and without square root transformation (SQRT)) was compared between eyes with and without ORT.

 
Results
 

103 fellow eyes with GA secondary to AMD, and OCT data at baseline and M18 were included in this study. 24 eyes showed evidence of ORT; in these eyes with ORT, the mean and median total area of GA was 7.94 and 7.75 mm2 at baseline, and increased to 9.62 and 9.85 mm2 at M18. In the 79 eyes without evidence of ORT, the mean and median total area of GA was 6.27 and 6.10 mm2 at baseline and increased to 8.67 and 9.30 mm2 at M18. Despite a larger baseline GA size, eyes with ORT showed a lower growth rate than eyes without ORT (1.68 ± 0.93 vs 2.40 ± 1.54, P=0. 003). This effect of ORT was observed regardless of whether the GA lesion was unifocal or multifocal (Table 1).

 
Conclusions
 

The growth rate of GA is slower in eyes with evidence of outer retinal tubulation on OCT compared to those without this finding.

  
Keywords: 412 age-related macular degeneration  
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