April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Multimodal Imaging Of Ghosts In Geographic Atrophy Areas
Author Affiliations & Notes
  • Eric H Souied
    Retina Creteil, University Paris Est, Creteil, France
  • Clemence Bonnet
    Retina Creteil, University Paris Est, Creteil, France
  • Hassiba Oubraham
    Retina Creteil, University Paris Est, Creteil, France
  • Rocio Blanco-Garavito
    Retina Creteil, University Paris Est, Creteil, France
  • Nathalie Puche
    Retina Creteil, University Paris Est, Creteil, France
  • Jennyfer Zerbib
    Retina Creteil, University Paris Est, Creteil, France
  • Giuseppe Querques
    Retina Creteil, University Paris Est, Creteil, France
  • Footnotes
    Commercial Relationships Eric Souied, Allergan (C), Bausch+Lomb (C), Bayer (C), Novartis (C), Thea (C); Clemence Bonnet, None; Hassiba Oubraham, None; Rocio Blanco-Garavito, Bayer (R); Nathalie Puche, None; Jennyfer Zerbib, None; Giuseppe Querques, bayer (C), novartis (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5886. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Eric H Souied, Clemence Bonnet, Hassiba Oubraham, Rocio Blanco-Garavito, Nathalie Puche, Jennyfer Zerbib, Giuseppe Querques; Multimodal Imaging Of Ghosts In Geographic Atrophy Areas. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5886.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract 
 
Purpose
 

To describe the multimodal imaging features of drusen-like lesions identified in areas of geographic atrophy (GA) in age-related macular degeneration (AMD) patients.

 
Methods
 

This is a retrospective case series of GA patients harboring lesions in atrophic areas. Multimodal imaging examination including infrared (IR) reflectance, fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) was performed for each patient. IR and FAF appearance and mean SD-OCT height of the structures in GA were analyzed.

 
Results
 

A total of 36 eyes of 25 patients (20 women; mean age 82.3±5.9 years, range 73-92 years) with GA were included. In all eyes, on IR reflectance images, drusen in GA appeared as hypereflective lesions surrounded by hyporeflective halos, within an area of background hypereflectivity due to GA. On FAF, drusen in GA appeared as hypoautofluorescent in most cases in 20/36 eyes (55.5%). On SD-OCT, drusen in GA appeared as hypereflective pyramidal structures (HPS). In 35/36 eyes (97.2%) the center was heterogeneously hypereflective, whereas the peripheral part of the HPS was hypereflective in all eyes (100%).

 
Conclusions
 

We describe a multimodal imaging of distinctive lesions. Because these HPS appear in GA areas, and because of their pyramidal or dome-shaped aspect on SD-OCT, we suggest the term of “macular ghosts”

 
Keywords: 412 age-related macular degeneration • 550 imaging/image analysis: clinical • 504 drusen  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×