April 2014
Volume 55, Issue 13
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ARVO Annual Meeting Abstract  |   April 2014
Choroidal thickness in geographic atrophy associated with age-related macular degeneration
Moritz Lindner; Joana Czauderna; Athanasios Bezatis; Eva Becker; Christian Karl Brinkmann; Rolf Fimmes; Steffen Schmitz-Valckenberg; Frank G Holz; Monika Fleckenstein; FAM Study Group
Author Affiliations & Notes
  • Moritz Lindner
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Joana Czauderna
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Athanasios Bezatis
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Eva Becker
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Christian Karl Brinkmann
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Rolf Fimmes
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany
  • Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
  • Footnotes
    Commercial Relationships Moritz Lindner, Carl Zeiss Meditec, Germany (F), Heidelberg Engineering, Germany (F), Optos, UK (F); Joana Czauderna, Carl Zeiss MediTec, Germany (F), Heidelberg Engineering, Germany (F), Optos, UK (F); Athanasios Bezatis, Carl Zeiss Meditec, Germany (F), Heidelberg Engineering, Germany (F), Optos, UK (F); Eva Becker, Carl Zeiss Meditec, Germany (F), Heidelberg Engineering, Germany (F), Optos, UK (F); Christian Brinkmann, Carl Zeiss Meditec, Germany (F), Heidelberg Engineering, Germany (F), Optos, UK (F); Rolf Fimmes, None; Steffen Schmitz-Valckenberg, Carl Zeiss Meditec, Germany (F), Heidelberg Engineering, Germany (F), Heidelberg Engineering, Germany (R), Optos, UK (F), Optos, UK (R); Frank Holz, Acucela, USA (C), Acucela, USA (F), Allergan, USA (C), Allergan, USA (F), Bayer, Germany (C), Bayer, Germany (F), Boehringer Ingelheim (C), Carl Zeiss Meditec, Germany (F), Genentech; USA (C), Genentech; USA (F), Heidelberg Engineering, Germany (C), Heidelberg Engineering, Germany (F), Merz, Germany (C), Novartis; Switzerland (C), Novartis; Switzerland (F), Optos, UK (F), Roche; Switzerland (C); Monika Fleckenstein, Carl Zeiss Meditec, Germany (F), Heidelberg Engineering, Germany (C), Heidelberg Engineering, Germany (F), Heidelberg Engineering, Germany (R), Optos, UK (C), Optos, UK (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5887. doi:
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      Moritz Lindner, Joana Czauderna, Athanasios Bezatis, Eva Becker, Christian Karl Brinkmann, Rolf Fimmes, Steffen Schmitz-Valckenberg, Frank G Holz, Monika Fleckenstein, FAM Study Group; Choroidal thickness in geographic atrophy associated with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5887.

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Abstract
 
Purpose
 

To compare choroidal thickness (CT) in different subtypes of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with normal controls.

 
Methods
 

A total of 42 eyes of 42 patients (mean age 76.2±6.5 y) with GA and 31 eyes of 31 healthy controls (mean age 75.6±6.4 y) were examined by confocal scanning-laser-ophthalmoscopy (cSLO) and EDI (enhanced depth imaging) SD-OCT (Spectralis, Heidelberg Engineering, Germany). CT was measured at 26 defined points in horizontal and vertical EDI-OCT scans for each patient. GA subtypes were classified based on abnormal FAF patterns surrounding the atrophic lesions as previsouly published (Holz et al.; Am J Ophthalmol 2007).

 
Results
 

Mean CT was significantly thinner in eyes with GA (168.47±88 µm) as compared to control eyes (215.5±55.6 µm, p=0.011). In the GA group, patients with the ‘diffuse trickling’ subtype (n=7, 108.7±31.9 µm) exhibited a significantly thinner CT as compared to other GA subtypes (‘non-diffuse trickling’ GA, n=35, 180.7±91.0 µm, p=0.047). Difference in CT between the ‘non-diffuse trickling’ GA eyes and control eyes were substantially less pronounced.

 
Conclusions
 

The results indicate that the choroid in eyes with GA is thinner compared to normal eyes of similar age. However, this effect appears to be mainly driven by a specific GA subtype (‘diffuse trickling’). Refined phenotypic classification of eyes with advanced dry AMD appears prudent when choroidal thickness is assessed and compared. GA-subtype related differences in choroidal thickness may reflect a heterogenous underlying pathogenesis.

 
Keywords: 412 age-related macular degeneration • 452 choroid • 550 imaging/image analysis: clinical  
© 2014, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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