April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Choroidal thickness changes in progressing geographic atrophy secondary to age-related macular degeneration
Author Affiliations & Notes
  • Elisabetta Pilotto
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Francesca Guidolin
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Enrica Convento
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Francesco Giuseppe Stefanon
    Department of Ophthalmology, University of Padova, Padova, Italy
  • Longhin Evelyn
    G.B. Bietti Foundation, IRCCS, Rome, Italy
  • Raffaele Parrozzani
    G.B. Bietti Foundation, IRCCS, Rome, Italy
  • Edoardo Midena
    Department of Ophthalmology, University of Padova, Padova, Italy
    G.B. Bietti Foundation, IRCCS, Rome, Italy
  • Footnotes
    Commercial Relationships Elisabetta Pilotto, None; Francesca Guidolin, None; Enrica Convento, None; Francesco Giuseppe Stefanon, None; Longhin Evelyn, None; Raffaele Parrozzani, None; Edoardo Midena, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5891. doi:https://doi.org/
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      Elisabetta Pilotto, Francesca Guidolin, Enrica Convento, Francesco Giuseppe Stefanon, Longhin Evelyn, Raffaele Parrozzani, Edoardo Midena; Choroidal thickness changes in progressing geographic atrophy secondary to age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5891. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To analyze, on a long term basis, choroidal thickness changes in patients with geographic atrophy (GA) secondary to age-related macular degeneration, with or without choroidal neovascularization (CNV) in the fellow eye.

 
Methods
 

In this prospective study, nineteen consecutive patients (27 eyes) affected by GA at least in one eye were enrolled. All eyes were studied, every 6 months, by means of: enhanced depth imaging spectral-domain optical coherence tomography to measure choroidal thickness; microperimetry to assess retinal sensitivity; blue (B-FAF) and near infrared-wavelenght fundus autofluorescence (NIR-FAF) to measure GA enlargement rate. Patients were divided in two groups: patients with bilateral GA (8 patients; 16 eyes) without evidence of CNV (bilateral GA group) along the study; patients with GA in one eye and CNV or disciform scar in the fellow eye (11 patients, fellow eye CNV group). In the fellow eye CNV group, CNV was present at baseline or developed during follow-up.

 
Results
 

Mean follow-up was 1.6 ± 0.76 years, without difference between the two study groups (p=0.6766). Choroid was significantly thicker in the bilateral GA group eyes compared to the fellow eye CNV group eyes at baseline (mean choroidal thickness: 170.5 ± 78.5 μm vs 129.1 ± 36.1 μm, p = 0.0371 ) and during follow-up (mean choroidal thickness: 173.2 ± 86.1 μm vs 123 ± 32.1 μm, p = 0.0340) . Mean choroidal thickness significantly decreased during follow-up only in the fellow eye CNV group (p=0.0276 in the fellow eye CNV group vs p= 0.4137 in the bilateral GA group). Mean GA area was not significantly different in the two groups neither at baseline nor at follow-up (p=0.4118 in B-FAF and p= 0.6806 in NIR-FAF at baseline, p= 0.5734 in B-FAF and p=0.8945 in NIR-FAF at follow-up) even if mean GA area significantly increased in both groups during follow-up. Mean retinal sensitivity significantly decreased during follow-up only in the bilateral GA group (p= 0.0405 in the bilateral GA group vs p=0.5634 in the fellow eye CNV group).

 
Conclusions
 

The choroid shows different changes in GA, probably reflecting different GA phenotypes. These results should be taken into consideration when planning clinical trials to treat GA, because the effect varies depending on the individual phenotype.

 
Keywords: 412 age-related macular degeneration • 550 imaging/image analysis: clinical • 452 choroid  
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