April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal oximetry in eyes with geographic atrophy due to age-related macular degeneration
Author Affiliations & Notes
  • Andreas Pollreisz
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Magdalena Baratsits
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Katharina Kefer
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Christoph Mitsch
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Stefan Sacu
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Ursula Schmidt-Erfurth
    Ophthalmology, Medical University Vienna, Vienna, Austria
  • Footnotes
    Commercial Relationships Andreas Pollreisz, None; Magdalena Baratsits, None; Katharina Kefer, None; Christoph Mitsch, None; Stefan Sacu, None; Ursula Schmidt-Erfurth, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5893. doi:
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      Andreas Pollreisz, Magdalena Baratsits, Katharina Kefer, Christoph Mitsch, Stefan Sacu, Ursula Schmidt-Erfurth; Retinal oximetry in eyes with geographic atrophy due to age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5893.

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Abstract
 
Purpose
 

To analyze oxygen saturation in retinal vessels of patients with geographic atrophy (GA) due to age-related macular degeneration (AMD).

 
Methods
 

Retinal oximetry was performed in retinal vessels with Oxymap T1 oximeter (Oxymap ehf., Reykjavik, Iceland), which is based on a fundus camera using spectrophotometric oxygen measurement. Two images with a wavelength of 600 nm (oxygen saturation sensitivity value) and 570 nm (oxygen-insensitive value) of the same fundus area were taken. 14 eyes of 10 patients with GA due to AMD were compared to 20 age-matched eyes of 10 patients with incipient AMD (Drusen only) or 20 eyes of 10 patients with no retinal diseases present (healthy controls). For each study participant the retinal arterial oxygen saturation, venous oxygen saturation and the arteriovenous (A-V) difference combined with the measurement of each vessel diameter were analyzed within a ring area concentric to the optic disc. Data are presented as mean ± standard deviation and significance calculated based on a paired t-test (p<0.05 considered statistically significant).

 
Results
 

The age of study participants ranged between 70 and 79 years, with no statistical significance observed between study cohorts. Mean oxygen saturation values of retinal venous vessels in patients with GA were significantly higher compared to healthy subjects or patients with incipient AMD (p=0.012; p=0.019). No statistical significance could be observed in the oxygen saturation of arterial vessels between the 3 study groups. Similarly, A-V difference showed no statistical significance between the study cohorts. The mean retinal vessel diameter of both venules and arterioles were not significantly different in patients with GA compared to eyes with incipient AMD or healthy controls.

 
Conclusions
 

Our results show that the oxygen saturation in retinal vessels was increased in venules of eyes with GA compared to healthy controls or eyes with early AMD. These data suggest that the oxygen delivery/consumption from the retinal circulation to the inner retina may be impaired in patients with GA.

 
Keywords: 412 age-related macular degeneration • 635 oxygen  
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