April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
MultiColor imaging in the evaluation of geographic atrophy due to age-related macular degeneration
Author Affiliations & Notes
  • Naima Ben Moussa
    Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Anouk Georges
    Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Eric H Souied
    Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France
  • Giuseppe Querques
    Ophthalmology, University Paris Est Creteil, Centre Hospitalier Intercommunal de Creteil, Creteil, France
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5898. doi:
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    • Get Citation

      Naima Ben Moussa, Anouk Georges, Eric H Souied, Giuseppe Querques, Eyes of patients with geographic atrophy due to dry AMD; MultiColor imaging in the evaluation of geographic atrophy due to age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5898.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate the ability of MultiColor imaging to evaluate geographic atrophy (GA) due to age-related macular degeneration.

 
Methods
 

Twenty-two consecutive patients with GA underwent MultiColor imaging, color fundus photography (CFP), blue light fundus autofluorescence (FAF) (excitation = 488 nm; emission > 500 nm), near-infrared fundus autofluorescence (NIR-FAF) (excitation = 787 nm; emission > 800 nm), and spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA + OCT; Heidelberg Engineering. Two readers independently made manually two measures at two different times of the size (area)and the width of GA (largest horizontal diameter through the fovea), and evaluated the foveal involvement in each exam.

 
Results
 

A total of 32 eyes (22 patients; 15 women, 7 men, mean age 79.2±8 years) with GA were included. Interindividual agreement according to the evaluation of the size and width of GA was high for all the exams. MultiColor and FAF showed the greatest interobserver agreement for GA area measure (ICC = 0,99, 95% confidence interval [CI], 0.98-0.99; ICC = 0,998, 95% confidence interval [CI], 0.996-0.999, respectively). The inter class correlation was equivalent between MutiColor, CFP and SD-OCT images in the evaluation of the width of GA on simultaneous SD-OCT scan passing through the fovea (ICC = 0,94, 95% confidence interval [CI], 0.88-0.9). SD-OCT showed the highest intergrader agreement of foveal involvement (k = 1) followed by MultiColor (k = 0,87).

 
Conclusions
 

All the modalities were reliable for measuring GA area and evaluating the presence of foveal sparing. MultiColor is an excellent imaging modality for the detection of foveal sparing and is very appropriate to the measure of GA area and width.

 
Keywords: 688 retina • 412 age-related macular degeneration • 550 imaging/image analysis: clinical  
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